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. 1985 Jul;55(3):463–471.

The analysis of an anti-fluorescein response at limit dilution: the effect of lymphokine preparations on the apparent specificity.

M A Skinner, R Prestidge, J Marbrook
PMCID: PMC1453633  PMID: 3926636

Abstract

The specificity of cytotoxic T cells in an anti-fluorescein response has been analysed at limit dilution. According to the ability to discriminate between fluoresceinated and non-fluoresceinated targets, the apparent specificity of CTL depends on the quality and quantity of the lymphokine preparations used to support the response. An acid-labile component of the factor preparations contributes to the generation of non-specific CTL. No cytotoxicity against NK-sensitive target cells was detected in the 'non-specific' component of the responses.

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Selected References

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