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. 1985 Oct;56(2):269–273.

Suppression of induced erythrocyte autoantibodies is dependent on Lyt 1 cells.

P Hutchings, S Marshall-Clarke, A Cooke
PMCID: PMC1453705  PMID: 2932385

Abstract

When normal mice are immunized with rat RBC, autoantibodies to mouse red cells and antigen-specific suppressor cells are generated. Suppressor cell activity is found in T-enriched populations and suppresses only the induction of autoantibody, not ongoing or secondary autoantibody responses. Using antibodies lytic for either B cells or distinct T-cell subpopulations, we are able to show that suppression is dependent on the presence of Lyt 1+ T cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Blackwell J. M., Ulczak O. M. Immunoregulation of genetically controlled acquired responses to Leishmania donovani infection in mice: demonstration and characterization of suppressor T cells in noncure mice. Infect Immun. 1984 Apr;44(1):97–102. doi: 10.1128/iai.44.1.97-102.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Chayen A., Parkhouse R. M. Preparation and properties of a cytotoxic monoclonal rat anti-mouse Thy-1 antibody. J Immunol Methods. 1982;49(1):17–23. doi: 10.1016/0022-1759(82)90362-3. [DOI] [PubMed] [Google Scholar]
  3. Cooke A., Hutchings P. R., Playfair J. H. Suppressor T cells in experimental autoimmune haemolytic anaemia. Nature. 1978 May 11;273(5658):154–155. doi: 10.1038/273154a0. [DOI] [PubMed] [Google Scholar]
  4. Cooke A., Hutchings P. Defective regulation of erythrocyte autoantibodies in SJL mice. Immunology. 1984 Mar;51(3):489–492. [PMC free article] [PubMed] [Google Scholar]
  5. Cooke A., Hutchings P., Marshall-Clarke S. Lack of autoantigen-specific splenic suppressor cells in mice with an X-linked B-lymphocyte defect. Immunology. 1980 Dec;41(4):815–818. [PMC free article] [PubMed] [Google Scholar]
  6. Cunningham A. J. Large numbers of cells in normal mice produce antibody components of isologous erythrocytes. Nature. 1974 Dec 20;252(5485):749–751. doi: 10.1038/252749a0. [DOI] [PubMed] [Google Scholar]
  7. Galfrè G., Milstein C., Wright B. Rat x rat hybrid myelomas and a monoclonal anti-Fd portion of mouse IgG. Nature. 1979 Jan 11;277(5692):131–133. doi: 10.1038/277131a0. [DOI] [PubMed] [Google Scholar]
  8. Hayakawa K., Hardy R. R., Honda M., Herzenberg L. A., Steinberg A. D., Herzenberg L. A. Ly-1 B cells: functionally distinct lymphocytes that secrete IgM autoantibodies. Proc Natl Acad Sci U S A. 1984 Apr;81(8):2494–2498. doi: 10.1073/pnas.81.8.2494. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Hutchings P., Cooke A. Analysis of the cellular interactions involved in the regulation of induced erythrocyte autoantibodies. Cell Immunol. 1981 Sep 15;63(2):221–227. doi: 10.1016/0008-8749(81)90001-0. [DOI] [PubMed] [Google Scholar]
  10. Julius M. H., Simpson E., Herzenberg L. A. A rapid method for the isolation of functional thymus-derived murine lymphocytes. Eur J Immunol. 1973 Oct;3(10):645–649. doi: 10.1002/eji.1830031011. [DOI] [PubMed] [Google Scholar]
  11. Liew F. Y., Sia D. Y., Parish C. R., McKenzie I. F. Major histocompatibility gene complex (MHC)-coded determinants on antigen-specific suppressor factor for delayed-type hypersensitivity and surface phenotypes of cells producing the factor. Eur J Immunol. 1980 Apr;10(4):305–309. doi: 10.1002/eji.1830100415. [DOI] [PubMed] [Google Scholar]
  12. Mond J. J., Scher I., Mosier D. E., Baese M., Paul W. E. T-independent responses in B cell-defective CBA/N mice to Brucella abortus and to trinitrophenyl (TNP) conjugates of Brucella abortus. Eur J Immunol. 1978 Jul;8(7):459–463. doi: 10.1002/eji.1830080703. [DOI] [PubMed] [Google Scholar]
  13. Naysmith J. D., Ortega-Pierres M. G., Elson C. J. Rat erythrocyte-induced anti-erythrocyte autoantibody production and control in normal mice. Immunol Rev. 1981;55:55–87. doi: 10.1111/j.1600-065x.1981.tb00339.x. [DOI] [PubMed] [Google Scholar]
  14. Pesoa S. A., Hayosh N. S., Swanborg R. H. Regulation of experimental allergic encephalomyelitis. Part 5. Role of the recipient in suppressor cell induction. J Neuroimmunol. 1984 Dec;7(2-3):131–135. doi: 10.1016/s0165-5728(84)80013-2. [DOI] [PubMed] [Google Scholar]
  15. Ramshaw I. A., McKenzie I. F., Bretscher P. A., Parish C. R. Discrimination of suppressor T cells of humoral and cell-mediated immunity by anti-Ly and anti-Ia sera. Cell Immunol. 1977 Jun 15;31(2):364–369. doi: 10.1016/0008-8749(77)90038-7. [DOI] [PubMed] [Google Scholar]
  16. Rittenberg M. B., Pratt K. L. Antitrinitrophenyl (TNP) plaque assay. Primary response of Balb/c mice to soluble and particulate immunogen. Proc Soc Exp Biol Med. 1969 Nov;132(2):575–581. doi: 10.3181/00379727-132-34264. [DOI] [PubMed] [Google Scholar]

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