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. 1985 Nov;56(3):451–457.

The effect of interferon treatment of targets on susceptibility to cytotoxic T-lymphocyte killing: augmentation of allogeneic killing and virus-specific killing relative to viral antigen expression.

M J Blackman, A G Morris
PMCID: PMC1453759  PMID: 2416676

Abstract

The effect on CTL lysis of treatment of CTL targets with IFNs has been investigated. Treatment of targets for alloreactive CTL with either IFN-alpha beta or IFN-gamma markedly augmented cytotoxicity. Cold competition experiments implied that CTL recognized the same target structure on both untreated and IFN-treated cells. This augmented lysis is presumably caused by IFN increasing expression of target MHC antigens. In the case of SFV-specific lysis of SFV-infected fibroblasts, IFN-alpha beta or IFN-gamma treatment somewhat reduced CTL lysis, but less so than Ab + C lysis which was abolished at moderate IFN concentrations; in the case of SFV-infected lymphoblastoid cells, CTL lysis remained the same or was slightly increased, whilst Ab + C lysis was reduced at moderate IFN concentrations and abolished at high IFN concentration; in the case of MSV/MLV-infected fibroblasts, CTL lysis was moderately increased whilst Ab + C lysis was decreased. IFN therefore increases virus-specific CTL cytotoxicity relative to viral antigen expression.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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