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. 1985 Aug;55(4):595–600.

Effect of FUT-175, a new synthetic protease inhibitor, on the development of lupus nephritis in (NZB x NZW) F1 mice.

S Ikehara, K Shimamura, T Aoyama, S Fujii, Y Hamashima
PMCID: PMC1453784  PMID: 4018844

Abstract

FUT-175 (6-amidino-2-naphthyl p-guanidinobenzoate dimethanesulphonate), a new synthetic protease inhibitor, was administrated to (NZB x NZB) F1 mice in order to examine its influence on the development of autoimmune diseases. A dose (400 mg/kg of body weight) of FUT-175 has both prophylactic and curative effects on the development of lupus nephritis: mice showed a significantly low percentage of proteinuria, a marked decrease in BUN levels, and the lowest degree of glomerular damages. Dexamethasone had almost the same effect as FUT-175 (400 mg/kg), but it was slightly less effective than FUT-175. These results suggest that the administration of FUT-175 may become a viable strategy for the treatment of human autoimmune diseases.

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Selected References

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  1. Aoyama T., Ino Y., Ozeki M., Oda M., Sato T., Koshiyama Y., Suzuki S., Fujita M. Pharmacological studies of FUT-175, nafamstat mesilate. I. Inhibition of protease activity in in vitro and in vivo experiments. Jpn J Pharmacol. 1984 Jul;35(3):203–227. doi: 10.1254/jjp.35.203. [DOI] [PubMed] [Google Scholar]
  2. Cochrane C. G., Müller-Eberhard H. J., Aikin B. S. Depletion of plasma complement in vivo by a protein of cobra venom: its effect on various immunologic reactions. J Immunol. 1970 Jul;105(1):55–69. [PubMed] [Google Scholar]
  3. Fujii S., Hitomi Y. New synthetic inhibitors of C1r, C1 esterase, thrombin, plasmin, kallikrein and trypsin. Biochim Biophys Acta. 1981 Oct 13;661(2):342–345. doi: 10.1016/0005-2744(81)90023-1. [DOI] [PubMed] [Google Scholar]
  4. Hitomi Y., Fujii S. Inhibition of various immunological reactions in vivo by a new synthetic complement inhibitor. Int Arch Allergy Appl Immunol. 1982;69(3):262–267. doi: 10.1159/000233181. [DOI] [PubMed] [Google Scholar]
  5. Ikari N., Sakai Y., Hitomi Y., Fujii S. New synthetic inhibitor to the alternative complement pathway. Immunology. 1983 Aug;49(4):685–691. [PMC free article] [PubMed] [Google Scholar]
  6. Ikehara S., Good R. A., Nakamura T., Sekita K., Inoue S., Oo M. M., Muso E., Ogawa K., Hamashima Y. Rationale for bone marrow transplantation in the treatment of autoimmune diseases. Proc Natl Acad Sci U S A. 1985 Apr;82(8):2483–2487. doi: 10.1073/pnas.82.8.2483. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Israel-Biet D., Noel L. H., Bach M. A., Dardenne M., Bach J. F. Marked reduction of DNA antibody production and glomerulopathy in thymulin (FTS-Zn) or cyclosporin A treated (NZB X NZW) F1 mice. Clin Exp Immunol. 1983 Nov;54(2):359–365. [PMC free article] [PubMed] [Google Scholar]
  8. Jungi T. W., McGregor D. D. Role of complement in the expression of delayed-type hypersensitivity in rats: studies with cobra venom factor. Infect Immun. 1979 Mar;23(3):633–643. doi: 10.1128/iai.23.3.633-643.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Otterness I. G., Torchia A. J., Doshan H. D. Complement inhibition by amidines and guanidines--in vivo and in vitro results. Biochem Pharmacol. 1978;27(14):1873–1878. doi: 10.1016/0006-2952(78)90035-7. [DOI] [PubMed] [Google Scholar]
  10. Schwartz H. J., Naff G. B. The effect of complement depletion by cobra venom factor on delayed hypersensitivity reactions. Proc Soc Exp Biol Med. 1971 Dec;138(3):1041–1043. doi: 10.3181/00379727-138-36046. [DOI] [PubMed] [Google Scholar]
  11. Shiraki M., Fujiwara M., Tomura S. Long term administration of cyclophosphamide in MRL/1 mice. I. The effects on the development of immunological abnormalities and lupus nephritis. Clin Exp Immunol. 1984 Feb;55(2):333–339. [PMC free article] [PubMed] [Google Scholar]
  12. Theofilopoulos A. N., Dixon F. J. Etiopathogenesis of murine SLE. Immunol Rev. 1981;55:179–216. doi: 10.1111/j.1600-065x.1981.tb00343.x. [DOI] [PubMed] [Google Scholar]
  13. Willoughby D. A., Polák L., Turk J. L. Suppression of contact hypersensitivity and acute inflammation by anti-complement serum. Nature. 1968 Jul 13;219(5150):192–193. doi: 10.1038/219192a0. [DOI] [PubMed] [Google Scholar]

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