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. 1986 Jan;57(1):49–53.

Transmission of maternal antibody prenatally and from milk into serum of neonatal rabbits.

B A Peri, R M Rothberg
PMCID: PMC1453894  PMID: 3943878

Abstract

Rabbit dams fed 0.1% BSA for various periods before and during lactation produced anti-BSA of low avidity and IgG isotype in serum and milk. Milk anti-BSA and IgG concentrations were one-third to one-half of those in the serum. At birth, kits had IgG and anti-BSA serum concentrations approximately equal to their dams. Both fell rapidly for the first 10-20 days, levelling off at about 1 mg IgG/ml. Kits born to unimmunized dams and suckled by dams with anti-BSA in the milk showed increasing anti-BSA in serum for the first 12-16 days, falling by 20 days. Foster-suckling on immunized dams beginning at various times after birth showed antibody uptake from birth through 12 days of age. Thus immunoglobulins are among factors absorbed from milk that have potential for regulating the immune responses of rabbit neonates.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adler F. L., Adler L. T. Consequences of prenatal exposure to maternal alloantigens. Ann N Y Acad Sci. 1982;392:266–275. doi: 10.1111/j.1749-6632.1982.tb36112.x. [DOI] [PubMed] [Google Scholar]
  2. Auerbach R., Clark S. Immunological tolerance: transmission from mother to offspring. Science. 1975 Sep 5;189(4205):811–813. doi: 10.1126/science.1162355. [DOI] [PubMed] [Google Scholar]
  3. DEICHMILLER M. P., DIXON F. J. The metabolism of serum proteins in neonatal rabbits. J Gen Physiol. 1960 Jul;43:1047–1059. doi: 10.1085/jgp.43.6.1047. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Iyengar L., Selvaraj R. J. Intestinal absorption of immunoglobulins by newborn infants. Arch Dis Child. 1972 Jun;47(253):411–414. doi: 10.1136/adc.47.253.411. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Jarrett E., Hall E. Selective suppression of IgE antibody responsiveness by maternal influence. Nature. 1979 Jul 12;280(5718):145–147. doi: 10.1038/280145a0. [DOI] [PubMed] [Google Scholar]
  6. Kleinman R. E., Harmatz P. R., Jacobson L. A., Udall J. N., Bloch K. J., Walker W. A. Passive transplacental immunization: influence on the detection of enteric antigen in the systemic circulation. Pediatr Res. 1983 Jun;17(6):449–451. doi: 10.1203/00006450-198306000-00003. [DOI] [PubMed] [Google Scholar]
  7. Kraehenbuhl J. P., Campiche M. A. Early stages of intestinal absorption of specific antibiodies in the newborn. An ultrastructural, cytochemical, and immunological study in the pig, rat, and rabbit. J Cell Biol. 1969 Aug;42(2):345–365. doi: 10.1083/jcb.42.2.345. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Peri B. A., Rothberg R. M. Specific suppression of antibody production in young rabbit kits after maternal ingestion of bovine serum albumin. J Immunol. 1981 Dec;127(6):2520–2525. [PubMed] [Google Scholar]
  9. Peri B. A., Theodore C. M., Losonsky G. A., Fishaut J. M., Rothberg R. M., Ogra P. L. Antibody content of rabbit milk and serum following inhalation or ingestion of respiratory syncytial virus and bovine serum albumin. Clin Exp Immunol. 1982 Apr;48(1):91–101. [PMC free article] [PubMed] [Google Scholar]
  10. Rao D. R., Sunki G. R., Johnson W. M., Chen C. P. Postnatal growth of New Zealand white rabbit (oryctolagus cuniculus). J Anim Sci. 1977 Jun;44(6):1021–1025. doi: 10.2527/jas1977.4461021x. [DOI] [PubMed] [Google Scholar]
  11. Roberts S. A., Turner M. W. Specific suppression of rat IgE responses with milk from immunized females and with feeds of serum antibody. Immunology. 1983 Jan;48(1):195–199. [PMC free article] [PubMed] [Google Scholar]
  12. Rothberg R. M., Kraft S. C., Farr R. S. Similarities between rabbit antibodies produced following ingestion of bovine serum albumin and following parenteral immunization. J Immunol. 1967 Feb;98(2):386–395. [PubMed] [Google Scholar]
  13. Sonoda S., Schlamowitz M. Kinetics and specificity of transfer of immunoglobulin G and serum albumin across rabbit yolk sac in utero. J Immunol. 1972 Mar;108(3):807–818. [PubMed] [Google Scholar]
  14. Walker W. A., Wu M., Isselbacher K. J., Bloch K. J. Intestinal uptake of macromolecules. III. Studies on the mechanism by which immunization interferes with antigen uptake. J Immunol. 1975 Sep;115(3):854–861. [PubMed] [Google Scholar]

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