Skip to main content
NCBI home page
Immunology logoLink to Immunology
. 1987 Oct;62(2):299–305.

Suppression of delayed-type hypersensitivity to histocompatibility antigens by ultraviolet radiation.

A Molendijk 1, R J van Gurp 1, I G Donselaar 1, R Benner 1
PMCID: PMC1453979  PMID: 2960612

Abstract

Delayed-type hypersensitivity (DTH) reactions to allogeneic histocompatibility antigens in mice could be systemically suppressed by a single exposure to UV-B irradiation. The extent of suppression reached its maximum 4 days after irradiation, gradually waned thereafter, and disappeared at Day 21. Re-exposure of these mice to UV-B after waning reinduced the state of suppression. The suppression could be transferred to naive mice by means of splenic T lymphocytes. The suppressor T (Ts) cells suppressed the proliferative activity in the lymph nodes draining the site of immunization, but not the activity of already activated DTH-reactive T cells. Phenotypical analysis of these Ts cells revealed that two subpopulations of T cells are involved: one with the Lyt-1+, 2- phenotype, the other with the Lyt-1-, 2+ phenotype.

Full text

PDF
299

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Austad J., Mørk N. J. Effects of short-wave ultraviolet light (UVB) on delayed hypersensitivity in the guinea pig. Acta Derm Venereol. 1982;62(2):133–136. [PubMed] [Google Scholar]
  2. Bianchi A. T., Hussaarts-Odijk L. M., Wolters E. A., Molendijk A., Benner R. Suppression of antigraft immunity by preimmunization. III. Characterization of suppressor T cells involved in suppression of the efferent phase of DTH against alloantigens. J Immunol. 1986 Jul 15;137(2):433–442. [PubMed] [Google Scholar]
  3. Bianchi A. T., Hussaarts-Odijk L. M., van der Kwast T. H., Bril H., Benner R. Suppression of antigraft immunity by preimmunization. II. Characterization of the suppressor cells. Transplantation. 1984 May;37(5):490–499. doi: 10.1097/00007890-198405000-00014. [DOI] [PubMed] [Google Scholar]
  4. Bril H., Molendijk-Lok B. D., Hussaarts-Odijk L. M., Benner R. Characterization of suppressor T cells in graft-versus-host reactions. Immunobiology. 1985 Apr;169(3):213–227. doi: 10.1016/S0171-2985(85)80035-8. [DOI] [PubMed] [Google Scholar]
  5. Bril H., Molendijk-Lok B. D., Hussaarts-Odijk L. M., Benner R. Synergism of T lymphocyte subsets in the response to Mls-locus coded antigens during graft-versus-host reaction. Cell Immunol. 1984 Feb;83(2):370–378. doi: 10.1016/0008-8749(84)90316-2. [DOI] [PubMed] [Google Scholar]
  6. De Fabo E. C., Noonan F. P. Mechanism of immune suppression by ultraviolet irradiation in vivo. I. Evidence for the existence of a unique photoreceptor in skin and its role in photoimmunology. J Exp Med. 1983 Jul 1;158(1):84–98. doi: 10.1084/jem.158.1.84. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. DeFabo E. C., Kripke M. L. Dose-response characteristics of immunologic unresponsiveness to UV-induced tumors produced by UV irradiation of mice. Photochem Photobiol. 1979 Sep;30(3):385–390. doi: 10.1111/j.1751-1097.1979.tb07372.x. [DOI] [PubMed] [Google Scholar]
  8. Elmets C. A., Bergstresser P. R., Tigelaar R. E., Wood P. J., Streilein J. W. Analysis of the mechanism of unresponsiveness produced by haptens painted on skin exposed to low dose ultraviolet radiation. J Exp Med. 1983 Sep 1;158(3):781–794. doi: 10.1084/jem.158.3.781. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Fisher M. S., Kripke M. L. Further studies on the tumor-specific suppressor cells induced by ultraviolet radiation. J Immunol. 1978 Sep;121(3):1139–1144. [PubMed] [Google Scholar]
  10. Fisher M. S., Kripke M. L. Systemic alteration induced in mice by ultraviolet light irradiation and its relationship to ultraviolet carcinogenesis. Proc Natl Acad Sci U S A. 1977 Apr;74(4):1688–1692. doi: 10.1073/pnas.74.4.1688. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Fox I. J., Sy M. S., Benacerraf B., Greene M. I. Impairment of antigen-presenting cell function by ultraviolet radiation. II. Effect of in vitro ultraviolet irradiation on antigen-presenting cells. Transplantation. 1981 Apr;31(4):262–265. doi: 10.1097/00007890-198104000-00006. [DOI] [PubMed] [Google Scholar]
  12. GRAY D. F., JENNINGS P. A. Allergy in experimental mouse tuberculosis. Am Rev Tuberc. 1955 Aug;72(2):171–195. doi: 10.1164/artpd.1955.72.2.171. [DOI] [PubMed] [Google Scholar]
  13. Harriott-Smith T. G., Halliday W. J. Circulating suppressor factors in mice subjected to ultraviolet irradiation and contact sensitization. Immunology. 1986 Feb;57(2):207–211. [PMC free article] [PubMed] [Google Scholar]
  14. Howie S. E., Norval M., Maingay J., Ross J. A. Two phenotypically distinct T cells (Ly1+2- and Ly1-2+) are involved in ultraviolet-B light-induced suppression of the efferent DTH response to HSV-1 in vivo. Immunology. 1986 Aug;58(4):653–658. [PMC free article] [PubMed] [Google Scholar]
  15. Kripke M. L. Immunological unresponsiveness induced by ultraviolet radiation. Immunol Rev. 1984 Aug;80:87–102. doi: 10.1111/j.1600-065x.1984.tb00496.x. [DOI] [PubMed] [Google Scholar]
  16. Kripke M. L., Lofgreen J. S., Beard J., Jessup J. M., Fisher M. S. In vivo immune responses of mice during carcinogenesis by ultraviolet irradiation. J Natl Cancer Inst. 1977 Oct;59(4):1227–1230. doi: 10.1093/jnci/59.4.1227. [DOI] [PubMed] [Google Scholar]
  17. Lynch D. H., Gurish M. F., Daynes R. A. The effects of high-dose UV exposure on murine Langerhans cell function at exposed and unexposed sites as assessed using in vivo and in vitro assays. J Invest Dermatol. 1983 Oct;81(4):336–341. doi: 10.1111/1523-1747.ep12519910. [DOI] [PubMed] [Google Scholar]
  18. Moorhead J. W. Tolerance and contact sensitivity to DNFB in mice. VI. Inhibition of afferent sensitivity by suppressor T cells in adoptive tolerance. J Immunol. 1976 Sep;117(3):802–806. [PubMed] [Google Scholar]
  19. Morison W. L., Pike R. A. Suppression of graft-versus-host reactivity in the mouse popliteal node by UVB radiation. J Invest Dermatol. 1985 Jun;84(6):483–486. doi: 10.1111/1523-1747.ep12272892. [DOI] [PubMed] [Google Scholar]
  20. Noonan F. P., Bucana C., Sauder D. N., De Fabo E. C. Mechanism of systemic immune suppression by UV irradiation in vivo. II. The UV effects on number and morphology of epidermal Langerhans cells and the UV-induced suppression of contact hypersensitivity have different wavelength dependencies. J Immunol. 1984 May;132(5):2408–2416. [PubMed] [Google Scholar]
  21. Noonan F. P., De Fabo E. C., Kripke M. L. Suppression of contact hypersensitivity by UV radiation and its relationship to UV-induced suppression of tumor immunity. Photochem Photobiol. 1981 Dec;34(6):683–689. [PubMed] [Google Scholar]
  22. Noonan F. P., Kripke M. L., Pedersen G. M., Greene M. I. Suppression of contact hypersensitivity in mice by ultraviolet irradiation is associated with defective antigen presentation. Immunology. 1981 Jul;43(3):527–533. [PMC free article] [PubMed] [Google Scholar]
  23. Rich S. S., Rich R. R. Regulatory mechanisms in cell-mediated immune responses. I. Regulation of mixed lymphocyte reactions by alloantigen-activated thymus-derived lymphocytes. J Exp Med. 1974 Dec 1;140(6):1588–1603. doi: 10.1084/jem.140.6.1588. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Spellman C. W., Daynes R. A. Modification of immunological potential by ultraviolet radiation. II. Generation of suppressor cells in short-term UV-irradiated mice. Transplantation. 1977 Aug;24(2):120–126. doi: 10.1097/00007890-197708000-00005. [DOI] [PubMed] [Google Scholar]
  25. Swartz R. P. Role of UVB-induced serum factor(s) in suppression of contact hypersensitivity in mice. J Invest Dermatol. 1984 Oct;83(4):305–307. doi: 10.1111/1523-1747.ep12340434. [DOI] [PubMed] [Google Scholar]
  26. Ullrich S. E., Kripke M. L. Mechanisms in the suppression of tumor rejection produced in mice by repeated UV irradiation. J Immunol. 1984 Nov;133(5):2786–2790. [PubMed] [Google Scholar]
  27. Ullrich S. E. Suppression of lymphoproliferation by hapten-specific suppressor T lymphocytes from mice exposed to ultraviolet radiation. Immunology. 1985 Feb;54(2):343–352. [PMC free article] [PubMed] [Google Scholar]
  28. Ullrich S. E. Suppression of the immune response to allogeneic histocompatibility antigens by a single exposure to ultraviolet radiation. Transplantation. 1986 Sep;42(3):287–291. doi: 10.1097/00007890-198609000-00012. [DOI] [PubMed] [Google Scholar]
  29. van der Kwast T. H., Benner R. T1 and T2 lymphocytes in primary and secondary delayed type hypersensitivity of mice. I. Contribution in the response to sheep red blood cells and to allogeneic spleen cells. Cell Immunol. 1978 Aug;39(1):194–203. doi: 10.1016/0008-8749(78)90093-x. [DOI] [PubMed] [Google Scholar]

Articles from Immunology are provided here courtesy of British Society for Immunology

RESOURCES