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. 1983 Mar;48(3):617–621.

Studies on T lymphocyte activation. II. Monoclonal antibody inhibiting the capacity of rat T lymphoblasts to absorb and to respond to IL-2: an anti-IL-2 receptor antibody?

H Osawa, T Diamantstein
PMCID: PMC1454026  PMID: 6600707

Abstract

We describe the production and some of the properties of a monoclonal antibody which inhibits binding of Interleukin 2 (IL-2) to rat T lymphoblasts as well as the capacity of these lymphoblasts to proliferate in response to IL-2 of rat or murine origin. According to these criteria, the antibody seems to be directed against an antigenic determinant on the IL-2 receptor. The antibody, obtained from hybridomas derived from mice immunized with phorbol-myristate-acetate-pulsed rat T lymphoblasts, exhibited species specificity, indicating that IL-2 receptors of various species are not necessarily identical, even if they can respond to IL-2 from different species.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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