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. 1983 Mar;48(3):519–527.

Comparative migration of T- and B-lymphocyte subpopulations into skin inflammatory sites.

A C van Dinther-Janssen, A C van Maarsseveen, J de Groot, R J Scheper
PMCID: PMC1454027  PMID: 6600705

Abstract

Homing of 51Cr-labelled spleen and lymph node-derived T- and B-cell subpopulations into inflammatory sites in the skin, as well as into lymphoid and non-lymphoid organs, was studied in outbred and inbred guinea-pigs. The early progeny of activated T cells were demonstrated in immunologically-mediated inflammation of the skin, for example a cell-mediated immune reaction and a reversed passive Arthus reaction. In contrast, spleen and lymph node-derived B cells were virtually unable to enter inflammatory sites. Organ-specific homing of T and B cells was detected. The significance of these observations for the interpretation of results of lymphoid cell transfers in guinea-pigs is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Allwood G. G. The migratory behavior of T blasts to contact sensitivity reactions in activelyand passively sensitized mice. Immunology. 1975 Apr;28(4):681–692. [PMC free article] [PubMed] [Google Scholar]
  2. Asherson G. L., Allwood G. G. Inflammatory lymphoid cells. Cells in immunized lymph nodes that move to sites of inflammation. Immunology. 1972 Mar;22(3):493–502. [PMC free article] [PubMed] [Google Scholar]
  3. Asherson G. L., Allwood G. G., Mayhew B. Contact sensitivity in the mouse. XI. Movement of T blasts in the draining lymph nodes to sites of inflammation. Immunology. 1973 Sep;25(3):485–494. [PMC free article] [PubMed] [Google Scholar]
  4. Askenase P. W. Cutaneous basophil hypersensitivity uncovered in the cell transfer of classical tuberculin hypersensitivity. J Immunol. 1976 Sep;117(3):741–747. [PubMed] [Google Scholar]
  5. Butcher E. C., Scollay R. G., Weissman I. L. Organ specificity of lymphocyte migration: mediation by highly selective lymphocyte interaction with organ-specific determinants on high endothelial venules. Eur J Immunol. 1980 Jul;10(7):556–561. doi: 10.1002/eji.1830100713. [DOI] [PubMed] [Google Scholar]
  6. Frost H. The effect of antigen on the output of recirculating T and B lymphocytes from single lymph nodes. Cell Immunol. 1978 May;37(2):390–396. doi: 10.1016/0008-8749(78)90207-1. [DOI] [PubMed] [Google Scholar]
  7. GOWANS J. L. The recirculation of lymphocytes from blood to lymph in the rat. J Physiol. 1959 Apr 23;146(1):54–69. doi: 10.1113/jphysiol.1959.sp006177. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Gillette R. W. Further evidence for the existence of B-lymphocyte subpopulations. Cell Immunol. 1979 Jun;45(1):26–35. doi: 10.1016/0008-8749(79)90359-9. [DOI] [PubMed] [Google Scholar]
  9. Gronowicz E., Coutinho A., Melchers F. A plaque assay for all cells secreting Ig of a given type or class. Eur J Immunol. 1976 Aug;6(8):588–590. doi: 10.1002/eji.1830060812. [DOI] [PubMed] [Google Scholar]
  10. Issekutz T. B., Chin W., Hay J. B. Lymphocyte traffic through granulomas: differences in the recovery of indium-111-labeled lymphocytes in afferent and efferent lymph. Cell Immunol. 1980 Aug 15;54(1):79–86. doi: 10.1016/0008-8749(80)90191-4. [DOI] [PubMed] [Google Scholar]
  11. Katz S. I., Parker D., Sommer G., Turk J. L. Suppressor cells in normal immunisation as a basic homeostatic phenomenon. Nature. 1974 Apr 12;248(449):612–614. doi: 10.1038/248612a0. [DOI] [PubMed] [Google Scholar]
  12. Lefford M. J. Properties of peritoneal exudate lymphocytes that mediate tuberculin delayed-type hypersensitivity and anti-tuberculosis immunity. I. The effect of cytotoxic agents. Immunology. 1980 Nov;41(3):635–642. [PMC free article] [PubMed] [Google Scholar]
  13. Manconi P. E. T lymphocytes bearing receptors for Fc of IgG in guinea pig peritoneal fluid. A model for human extrahaematic fluids. Int Arch Allergy Appl Immunol. 1977;55(1-6):126–130. doi: 10.1159/000231918. [DOI] [PubMed] [Google Scholar]
  14. Morgan K., Holt P. J. Migration of human lymphocytes. I. A model using the mouse as host. Immunology. 1978 Nov;35(5):695–705. [PMC free article] [PubMed] [Google Scholar]
  15. Morito T., Tanimoto K., Hashimoto Y., Horiuchi Y., Juji T. Fc-rosette inhibition by hypocomplementaemic systemic lupus erythematosus sera. Ann Rheum Dis. 1975 Oct;35(5):415–421. doi: 10.1136/ard.35.5.415. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Nieuwenhuis P., Ford W. L. Comparative migration of B- and T-Lymphocytes in the rat spleen and lymph nodes. Cell Immunol. 1976 May;23(2):254–267. doi: 10.1016/0008-8749(76)90191-x. [DOI] [PubMed] [Google Scholar]
  17. Parker D., Turk J. L., Scheper R. J. Central and peripheral action of suppressor cells in contact sensitivity in the guinea-pig. Immunology. 1976 Apr;30(4):593–597. [PMC free article] [PubMed] [Google Scholar]
  18. Ranne G. H., Smith M. E., Ford W. L. Lymphocyte migration into cell-mediated immune lesions is inhibited by trypsin. Nature. 1977 Jun 9;267(5611):520–522. doi: 10.1038/267520a0. [DOI] [PubMed] [Google Scholar]
  19. Rose M. L., Parrott D. M., Bruce R. G. The accumulation of immunoblasts in extravascular tissues including mammary gland, peritoneal cavity, gut and skin. Immunology. 1978 Aug;35(2):415–423. [PMC free article] [PubMed] [Google Scholar]
  20. Scheper R. J., Polak L. Characterization of lymphocyte subpopulations which exhibit enhanced DNA synthesis in vitro in DNFB contact sensitive guinea-pigs. Immunology. 1981 Jul;43(3):563–572. [PMC free article] [PubMed] [Google Scholar]
  21. Scheper R. J., van Maarsseveen T. C., van Dinther-Janssen A. C. Comparative migration of guinea pig T and B lymphocytes from capillary tubes. Cell Immunol. 1980 Jul 15;53(1):19–28. doi: 10.1016/0008-8749(80)90422-0. [DOI] [PubMed] [Google Scholar]
  22. Scollay R., Hopkins J., Hall J. Possible role of surface Ig in non-random recirculation of small lymphocytes. Nature. 1976 Apr 8;260(5551):528–529. doi: 10.1038/260528a0. [DOI] [PubMed] [Google Scholar]
  23. Sprent J. Circulating T and B lymphocytes of the mouse. I. Migratory properties. Cell Immunol. 1973 Apr;7(1):10–39. doi: 10.1016/0008-8749(73)90180-9. [DOI] [PubMed] [Google Scholar]
  24. Stashenko P. P., Bhan A. K., Schlossman S. F., McCluskey R. T. Local transfer of delayed hypersensitivity and cutaneous basophil hypersensitivity. J Immunol. 1977 Dec;119(6):1987–1993. [PubMed] [Google Scholar]
  25. TURK J. L., LEIBOWITZ S. FAILURE OF CELLULAR TRANSFER OF TUBERCULIN SENSITIVITY BETWEEN GUINEA PIGS OF DIFFERENT STRAINS. Nature. 1964 May 16;202:713–714. doi: 10.1038/202713a0. [DOI] [PubMed] [Google Scholar]
  26. Van Boxel J. A., Paget S. A. Predominantly T-cell infiltrate in rheumatoid synovial membranes. N Engl J Med. 1975 Sep 11;293(11):517–520. doi: 10.1056/NEJM197509112931101. [DOI] [PubMed] [Google Scholar]
  27. Zatz M. M., Gingrich R., Lance E. M. The effect of histocompatibility antigens on lymphocyte migration in the mouse. Immunology. 1972 Nov;23(5):665–675. [PMC free article] [PubMed] [Google Scholar]
  28. von Willebrand E., Horsmanheimo M., Kiistala U., Häyry P. Analysis of intracutaneous inflammatory lesions with skin blisters. I. Cytological characterization and subclass distribution of lymphocytes infiltrating purified protein derivative-induced inflammatory lesions. Clin Immunol Immunopathol. 1978 Dec;11(4):445–457. doi: 10.1016/0090-1229(78)90172-1. [DOI] [PubMed] [Google Scholar]

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