Abstract
In our earlier studies we have observed that T lymphocytes of dengue type 2 virus (DV)-infected mouse spleen produce a cytotoxic factor (CF). In the present study it has been observed that CF induces mouse spleen and peritoneal macrophages to produce a cytotoxin (CF2) as has been revealed by DEAE-cellulose chromatography. CF2 is produced by an induction process and is present intracellularly as well as leaking out of the cells. CF2 kills most of the macrophages and some of the T cells, as observed with CF. It appears that CF2 is produced to amplify the effect of CF and/or for cooperative action with CF.
Full text
PDF









Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Agrawal D. K., Tandon P., Chaturvedi U. C., Kumar A. Biochemical study of certain enzymes and metabolites of the carbohydrate metabolism in the skeletal muscle of the dengue virus-infected mice. J Gen Virol. 1978 Aug;40(2):399–408. doi: 10.1099/0022-1317-40-2-399. [DOI] [PubMed] [Google Scholar]
- Chaturvedi U. C., Bhargava A., Mathur A. Production of cytotoxic factor in the spleen of dengue virus-infected mice. Immunology. 1980 Aug;40(4):665–671. [PMC free article] [PubMed] [Google Scholar]
- Chaturvedi U. C., Dalakoti H., Mathur A. Characterization of the cytotoxic factor produced in the spleen of dengue virus-infected mice. Immunology. 1980 Oct;41(2):387–392. [PMC free article] [PubMed] [Google Scholar]
- Chaturvedi U. C., Gulati L., Mathur A. Inhibition of E-rosette formation and phagocytosis by human blood leucocytes after treatment with the dengue virus-induced cytotoxic factor. Immunology. 1982 Apr;45(4):679–685. [PMC free article] [PubMed] [Google Scholar]
- Chaturvedi U. C., Shukla M. I., Mathur K. R., Mathur A. Dengue virus-induced cytotoxic factor suppresses immune response of mice to sheep erythrocytes. Immunology. 1981 Jun;43(2):311–316. [PMC free article] [PubMed] [Google Scholar]
- Chaturvedi U. C., Shukla M. I. [Characterization of the suppressor factor produced in the spleen of dengue virus-infected mice]. Ann Immunol (Paris) 1981 May-Jun;132C(3):245–255. doi: 10.1016/0769-2625(81)90075-1. [DOI] [PubMed] [Google Scholar]
- Chaturvedi U. C., Tandon H. O., Mathur A. Control of in vitro and in vivo spread of coxsackievirus B4 infection by sensitized spleen cells and antibody. J Infect Dis. 1978 Aug;138(2):181–190. doi: 10.1093/infdis/138.2.181. [DOI] [PubMed] [Google Scholar]
- Chaturvedi U. C., Tandon P., Mathur A. Effect of immunosuppression on dengue virus infection in mice. J Gen Virol. 1977 Sep;36(3):449–458. doi: 10.1099/0022-1317-36-3-449. [DOI] [PubMed] [Google Scholar]
- Chaturvedi U. C., Tandon P., Mathur A., Kumar A. Host defence mechanisms against dengue virus infection of mice. J Gen Virol. 1978 May;39(2):293–302. doi: 10.1099/0022-1317-39-2-293. [DOI] [PubMed] [Google Scholar]
- Cowing C., Schwartz B. D., Dickler H. B. Macrophage Ia antigens. I. macrophage populations differ in their expression of Ia antigens. J Immunol. 1978 Feb;120(2):378–384. [PubMed] [Google Scholar]
- Dalakoti H., Chaturvedi U. C., Mathur A. Inhibition of production of dengue virus induced cytotoxic factor by treatment with cycloheximide & mitomycin C. Indian J Exp Biol. 1982 Jan;20(1):1–3. [PubMed] [Google Scholar]
- Gulati L., Chaturvedi U. C., Mathur A. Depressed macrophage functions in dengue virus-infected mice: role of the cytotoxic factor. Br J Exp Pathol. 1982 Apr;63(2):194–202. [PMC free article] [PubMed] [Google Scholar]
- Julius M. H., Simpson E., Herzenberg L. A. A rapid method for the isolation of functional thymus-derived murine lymphocytes. Eur J Immunol. 1973 Oct;3(10):645–649. doi: 10.1002/eji.1830031011. [DOI] [PubMed] [Google Scholar]
- Shukla M. I., Chaturvedi U. C. Cycloheximide & mitomycin C inhibited production of dengue virus-induced suppressor factor. Indian J Exp Biol. 1981 Sep;19(9):826–828. [PubMed] [Google Scholar]
- Shukla M. I., Chaturvedi U. C. Dengue virus-induced suppressor factor stimulates production of prostaglandin to mediate suppression. J Gen Virol. 1981 Oct;56(Pt 2):241–249. doi: 10.1099/0022-1317-56-2-241. [DOI] [PubMed] [Google Scholar]
- Shukla M. I., Chaturvedi U. C. In vivo role of macrophages in transmission of dengue virus-induced suppressor signal to T lymphocytes. Br J Exp Pathol. 1982 Oct;63(5):522–530. [PMC free article] [PubMed] [Google Scholar]
- Shukla M. I., Chaturvedi U. C. Transmission of dengue virus-induced suppressor signal from macrophage to lymphocyte occurs by cell contact. Br J Exp Pathol. 1983 Feb;64(1):87–92. [PMC free article] [PubMed] [Google Scholar]
- Shukla M. I., Dalakoti H., Chaturvedi U. C. Ly phenotype of T lymphocytes producing dengue virus-induced immunosuppressive factors. Indian J Exp Biol. 1982 Jul;20(7):525–528. [PubMed] [Google Scholar]
- Tandon P., Chaturvedi U. C., Mathur A. Dengue virus-induced thymus-derived suppressor cells in the spleen of mice. Immunology. 1979 Dec;38(4):653–658. [PMC free article] [PubMed] [Google Scholar]
- Trizio D., Cudkowicz G. Separation of T and B lymphocytes by nylon wool columns: evaluation of efficacy by functional assays in vivo. J Immunol. 1974 Oct;113(4):1093–1097. [PubMed] [Google Scholar]