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. 1983 Jun;49(2):239–244.

Association of human leucocyte low responsiveness to inducers of interferon alpha with HLA-DR 2.

J Abb, H Zander, H Abb, E Albert, F Deinhardt
PMCID: PMC1454175  PMID: 6406360

Abstract

The influence of antigens of the major histocompatibility complex (MHC) on the production of interferon (IFN) alpha or IFN gamma by human peripheral blood leucocytes (PBL) in vitro has been studied. Synthesis of IFN gamma by PBL stimulated with purified phytohaemagglutinin (PHA-P) or protein A of Staphylococcus aureus (SpA) appeared not to be controlled by MHC antigens. The production of IFN alpha, however, was influenced by the HLA type of the donor. Low responsiveness of PBL to inducers of IFN alpha (influenza virus, Molt 4 cells) was associated with HLA-DR 2. Implications of these observations for studies of IFN production and natural killer (NK) cell activity are discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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