Abstract
The intestine immune response in rats following immunization with horseradish peroxidase (HRP) was studied morphologically. Various routes of immunization (intraperitoneal, intravenous, intraenteric and intra-Peyer's patch) were tested. Single injections did not evoke any specific antibody-containing (anti-HRP) cells in Peyers' patches (PP) and lamina propria of the small intestine. Only an intraperitoneal or intraenteric booster injection following intraperitoneal priming induced the formation of anti-HRP cells in PP and lamina propria. In the initial period of the immune response most of the anti-HRP cells were blast cells which were located mainly within the thymus-dependent interfollicular area of PP. Later on in the immune response more than 90% of the anti-HRP cells were located in the lamina propria of the villi and had the morphology of plasma cells.
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