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. 1988 Feb;63(2):199–203.

An investigation of the nature of induced suppression to experimental autoimmune thyroiditis.

N M Parish 1, D Rayner 1, A Cooke 1, I M Roitt 1
PMCID: PMC1454523  PMID: 2450834

Abstract

When mice are pretreated with soluble mouse thyroglobulin (MTg), subsequent induction of autoantibodies in experimental allergic thyroiditis (EAT) is suppressed. This suppression can be reproducibly transferred to low-level irradiated syngeneic recipients and is specific for MTg. Injection of normal cells does not reverse this tolerance, also indicative of an active suppression. Neither can the induced unresponsiveness be overcome by immunization with cross-reactive xenogeneic Tg; although antibodies are formed which will bind to MTg, these are not to epitopes to which antibodies are normally formed on immunization or towards which tolerance is induced. This implies that tolerance might be induced at least at the B-cell level, a view supported by the inability of DNP to provide a new carrier to break tolerance when conjugated to MTg. The poorer response to DNP in these animals also suggests anergy of the MTg-specific T helpers.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Benjamin D. C., Weigle W. O. The termination of immunological unresponsiveness to bovine serum albumin in rabbits. I. Quantitative and qualitative response to cross-reacting albumins. J Exp Med. 1970 Jul 1;132(1):66–76. doi: 10.1084/jem.132.1.66. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Champion B. R., Page K., Rayner D. C., Quartey-Papafio R., Byfield P. G., Henderson G. Recognition of thyroglobulin autoantigenic epitopes by murine T and B cells. Immunology. 1987 Oct;62(2):255–263. [PMC free article] [PubMed] [Google Scholar]
  3. HUMPHREY J. H. IMMUNOLOGICAL UNRESPONSIVENESS TO PROTEIN ANTIGENS IN RABBITS. I. THE DURATION OF UNRESPONSIVENESS FOLLOWING A SINGLE INJECTION AT BIRTH. Immunology. 1964 Jul;7:449–461. [PMC free article] [PubMed] [Google Scholar]
  4. Kong Y. M., Okayasu I., Giraldo A. A., Beisel K. W., Sundick R. S., Rose N. R., David C. S., Audibert F., Chedid L. Tolerance to thyroglobulin by activating suppressor mechanisms. Ann N Y Acad Sci. 1982;392:191–209. doi: 10.1111/j.1749-6632.1982.tb36108.x. [DOI] [PubMed] [Google Scholar]
  5. Male D. K., Champion B. R., Pryce G., Matthews H., Shepherd P. Antigenic determinants of human thyroglobulin differentiated using antigen fragments. Immunology. 1985 Mar;54(3):419–427. [PMC free article] [PubMed] [Google Scholar]
  6. Rose N. R., Twarog F. J., Crowle A. J. Murine thyroiditis: importance of adjuvant and mouse strain for the induction of thyroid lesions. J Immunol. 1971 Mar;106(3):698–704. [PubMed] [Google Scholar]
  7. Weigle W. O. Recent observations and concepts in immunological unresponsiveness and autoimmunity. Clin Exp Immunol. 1971 Oct;9(4):437–447. [PMC free article] [PubMed] [Google Scholar]

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