Abstract
Male lymphocytic choriomeningitis (LCM) virus-carrier mice were mated to uninfected females and their offsprings tested for (i) LCMV virus and (ii) their potential to generate LCM virus-specific cytotoxic T cells. Among about 500 offspring tested no example of antigen-independent inheritance of tolerance to LCM virus was detected. Therefore inheritance of acquired tolerance cannot be observed in this murine infectious disease model.
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Selected References
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- Brent L., Rayfield L. S., Chandler P., Fierz W., Medawar P. B., Simpson E. Supposed lamarckian inheritance of immunological tolerance. Nature. 1981 Apr 9;290(5806):508–512. doi: 10.1038/290508a0. [DOI] [PubMed] [Google Scholar]
- Buchmeier M. J., Welsh R. M., Dutko F. J., Oldstone M. B. The virology and immunobiology of lymphocytic choriomeningitis virus infection. Adv Immunol. 1980;30:275–331. doi: 10.1016/s0065-2776(08)60197-2. [DOI] [PubMed] [Google Scholar]
- Gorczynski R. M., Steele E. J. Inheritance of acquired immunological tolerance to foreign histocompatibility antigens in mice. Proc Natl Acad Sci U S A. 1980 May;77(5):2871–2875. doi: 10.1073/pnas.77.5.2871. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gorczynski R. M., Steele E. J. Simultaneous yet independent inheritance of somatically acquired tolerance to two distinct H-2 antigenic haplotype determinants in mice. Nature. 1981 Feb 19;289(5799):678–681. doi: 10.1038/289678a0. [DOI] [PubMed] [Google Scholar]
- Hasek M., Holán V., Kousalová M. Different states of transplantation tolerance, and the problem of inheritance of tolerance. Immunol Lett. 1981 Aug;3(3):183–186. doi: 10.1016/0165-2478(81)90125-5. [DOI] [PubMed] [Google Scholar]
- McLaren A., Chandler P., Buehr M., Fierz W., Simpson E. Immune reactivity of progeny of tetraparental male mice. Nature. 1981 Apr 9;290(5806):513–514. doi: 10.1038/290513a0. [DOI] [PubMed] [Google Scholar]
- Müllbacher A., Ashman R. B., Blanden R. V. Induction of T cell hyporesponsiveness to Bebaru in mice, and abnormalities in the immune responses of progeny of hyporesponsive males. Aust J Exp Biol Med Sci. 1983 Apr;61(Pt 2):187–191. doi: 10.1038/icb.1983.17. [DOI] [PubMed] [Google Scholar]
- Nisbet-Brown E., Wegmann T. G. Is acquired immunological tolerance genetically transmissible? Proc Natl Acad Sci U S A. 1981 Sep;78(9):5826–5828. doi: 10.1073/pnas.78.9.5826. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tosolini F. A., Mims C. A. Effect of murine strain and viral strain on the pathogenesis of lymphocytic choriomeningitis infection and a study of footpad responses. J Infect Dis. 1971 Feb;123(2):134–144. doi: 10.1093/infdis/123.2.134. [DOI] [PubMed] [Google Scholar]