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. 1984 Sep;53(1):155–163.

Impaired resistance to Listeria monocytogenes in mice chronically exposed to cadmium.

M Simonet, P Berche, J L Fauchere, M Veron
PMCID: PMC1454730  PMID: 6332063

Abstract

It is shown in this work that resistance to Listeria monocytogenes is greatly impaired in C57BL/6 mice chronically exposed to cadmium (Cd) chloride. Animals received 0.5 mg/kg Cd by an intraperitoneal route three times a week during a 4-week period and were then infected with L. monocytogenes. Susceptibility to this pathogenic bacteria was not due to a defect of the specific immune response, since mice developed normal levels of anti-Listeria T cell-mediated immunity and did not show any impairment of macrophage activation. In fact, bacterial growth in organs was rapid in Cd-exposed mice during the early phase of infection, suggesting an impairment of non-specific defence mechanisms. Experimental data indicate that the susceptibility to L. monocytogenes might be due to a defect of macrophage recruitment in sites of infection during the early phase of the host response.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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