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. 1988 Mar;63(3):447–449.

Absence of any male-specific antigen recognized by T lymphocytes in X/XSxr' male mice.

A McLaren 1, R Hunt 1, E Simpson 1
PMCID: PMC1454747  PMID: 3280475

Abstract

Previous work has established that whereas X/X mice carrying the sex-reversing chromosomal fragment Sxr are positive for the male-specific transplantation antigen, H-Y, X/X mice carrying the variant Sxr', although they too develop as phenotypic males, are H-Y negative. In this paper we show that X/XSxr' male mice do not express any male-specific antigen that can induce skin-graft rejection.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bennett D., Mathieson B. J., Scheid M., Yanagisawa K., Boyse E. A., Wachtel S., Cattanach B. M. Serological evidence for H-Y antigen in Sxr, XX sex-reversal phenotypic males. Nature. 1977 Jan 20;265(5591):255–257. doi: 10.1038/265255a0. [DOI] [PubMed] [Google Scholar]
  2. McLaren A., Monk M. Fertile females produced by inactivation of an X chromosome of "sex-reversed' mice. Nature. 1982 Dec 2;300(5891):446–448. doi: 10.1038/300446a0. [DOI] [PubMed] [Google Scholar]
  3. McLaren A., Simpson E., Tomonari K., Chandler P., Hogg H. Male sexual differentiation in mice lacking H-Y antigen. Nature. 1984 Dec 6;312(5994):552–555. doi: 10.1038/312552a0. [DOI] [PubMed] [Google Scholar]
  4. Silvers W. K., Gasser D. L., Eicher E. M. H-Y antigen, serologically detectable male antigen and sex determination. Cell. 1982 Mar;28(3):439–440. doi: 10.1016/0092-8674(82)90197-0. [DOI] [PubMed] [Google Scholar]
  5. Simpson E., Chandler P., Hunt R., Hogg H., Tomonari K., McLaren A. H-Y status of X/X Sxr' male mice: in vivo tests. Immunology. 1986 Mar;57(3):345–349. [PMC free article] [PubMed] [Google Scholar]
  6. Simpson E., Edwards P., Wachtel S., McLaren A., Chandler P. H-Y antigen in Sxr mice detected by H-2-restricted cytotoxic T cells. Immunogenetics. 1981;13(4):355–358. doi: 10.1007/BF00364502. [DOI] [PubMed] [Google Scholar]
  7. Singh L., Jones K. W. Sex reversal in the mouse (Mus musculus) is caused by a recurrent nonreciprocal crossover involving the x and an aberrant y chromosome. Cell. 1982 Feb;28(2):205–216. doi: 10.1016/0092-8674(82)90338-5. [DOI] [PubMed] [Google Scholar]

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