Abstract
We have investigated the genetic basis of oral tolerance to OVA in a number of inbred mouse strains. Our results emphasise the efficiency of the oral route for inducing tolerance and provide evidence for both MHC and non-MHC linked control of oral tolerance.
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- Azar M. M., Ranges G. E., Yunis E. J., Clark C. Genetic control of tolerance induction to human gamma-globulin in mice. J Immunol. 1978 Oct;121(4):1251–1256. [PubMed] [Google Scholar]
- Howell M. D., Austin R. K., Kelleher D., Nepom G. T., Kagnoff M. F. An HLA-D region restriction fragment length polymorphism associated with celiac disease. J Exp Med. 1986 Jul 1;164(1):333–338. doi: 10.1084/jem.164.1.333. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lamont A. G., Gordon M., Ferguson A. Oral tolerance in protein-deprived mice. I. Profound antibody tolerance but impaired DTH tolerance after antigen feeding. Immunology. 1987 Jul;61(3):333–337. [PMC free article] [PubMed] [Google Scholar]
- Mowat A. M., Lamont A. G., Bruce M. G. A genetically determined lack of oral tolerance to ovalbumin is due to failure of the immune system to respond to intestinally derived tolerogen. Eur J Immunol. 1987 Nov;17(11):1673–1676. doi: 10.1002/eji.1830171126. [DOI] [PubMed] [Google Scholar]
- Passwell J. H., Dayer J. M., Merler E. Increased prostaglandin production by human monocytes after membrane receptor activation. J Immunol. 1979 Jul;123(1):115–120. [PubMed] [Google Scholar]
- Stokes C. R., Swarbrick E. T., Soothill J. F. Genetic differences in immune exclusion and partial tolerance to ingested antigens. Clin Exp Immunol. 1983 Jun;52(3):678–684. [PMC free article] [PubMed] [Google Scholar]
- Tomasi T. B., Barr W. G., Challacombe S. J., Curran G. Oral tolerance and accessory-cell function of Peyer's patches. Ann N Y Acad Sci. 1983 Jun 30;409:145–163. doi: 10.1111/j.1749-6632.1983.tb26865.x. [DOI] [PubMed] [Google Scholar]