Skip to main content
PMC home page
Immunology logoLink to Immunology
. 1988 Apr;63(4):707–714.

Expression of class II MHC gene products by macrophages in human uteroplacental tissue.

J N Bulmer 1, L Morrison 1, J C Smith 1
PMCID: PMC1454811  PMID: 3284818

Abstract

The expression of class II MHC determinants by fetal and maternal macrophages in human uteroplacental tissues was examined with monoclonal antibodies directed against HLA-DR, DP and DQ antigens. Maternal macrophages in early and full-term pregnancy decidua were HLA-DR positive, and a substantial proportion also expressed DP and DQ antigens. Fetal macrophages in chorionic villous stroma in first-trimester pregnancy were rarely HLA-DR positive, and DQ and DP antigens were never expressed. In term placental tissues, groups of villous stromal macrophages were HLA-DR positive, as were fetal macrophages within amniotic mesenchyme. In contrast, DP and DQ antigens were detected on a small minority of fetal macrophages in term placental tissues. DP and DQ antigens were not detected in the absence of DR antigens.

Full text

PDF
707

Images in this article

709Figure 1
on p.709
710Figure 2
on p.710
711Figure 3
on p.711
712Figure 4
on p.712
712Figure 5
on p.712

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brami C. J., Sanyal M. K., Dwyer J. M., Johnson C. C., Kohorn E. I., Naftolin F. HLA-DR antigen on human trophoblast. Am J Reprod Immunol. 1983 Jun;3(4):165–174. doi: 10.1111/j.1600-0897.1983.tb00240.x. [DOI] [PubMed] [Google Scholar]
  2. Brodsky F. M. A matrix approach to human class II histocompatibility antigens: reactions of four monoclonal antibodies with the products of nine haplotypes. Immunogenetics. 1984;19(3):179–194. doi: 10.1007/BF00364762. [DOI] [PubMed] [Google Scholar]
  3. Bulmer J. N., Johnson P. M. Macrophage populations in the human placenta and amniochorion. Clin Exp Immunol. 1984 Aug;57(2):393–403. [PMC free article] [PubMed] [Google Scholar]
  4. Bulmer J. N., Sunderland C. A. Immunohistological characterization of lymphoid cell populations in the early human placental bed. Immunology. 1984 Jun;52(2):349–357. [PMC free article] [PubMed] [Google Scholar]
  5. Chen Y. X., Evans R. L., Pollack M. S., Lanier L. L., Phillips J. H., Rousso C., Warner N. L., Brodsky F. M. Characterization and expression of the HLA-DC antigens defined by anti-Leu 10. Hum Immunol. 1984 Aug;10(4):221–235. doi: 10.1016/0198-8859(84)90088-0. [DOI] [PubMed] [Google Scholar]
  6. Edwards J. A., Durant B. M., Jones D. B., Evans P. R., Smith J. L. Differential expression of HLA class II antigens in fetal human spleen: relationship of HLA-DP, DQ, and DR to immunoglobulin expression. J Immunol. 1986 Jul 15;137(2):490–497. [PubMed] [Google Scholar]
  7. Edwards J. A., Jones D. B., Evans P. R., Smith J. L. Differential expression of HLA class II antigens on human fetal and adult lymphocytes and macrophages. Immunology. 1985 Jul;55(3):489–500. [PMC free article] [PubMed] [Google Scholar]
  8. Ellis S. A., Sargent I. L., Redman C. W., McMichael A. J. Evidence for a novel HLA antigen found on human extravillous trophoblast and a choriocarcinoma cell line. Immunology. 1986 Dec;59(4):595–601. [PMC free article] [PubMed] [Google Scholar]
  9. Fischer A., Sterkers G., Charron D., Durandy A. HLA class II restriction governing cell cooperation between antigen-specific helper T lymphocytes, B lymphocytes and monocytes for in vitro antibody production to influenza virus. Eur J Immunol. 1985 Jun;15(6):620–626. doi: 10.1002/eji.1830150617. [DOI] [PubMed] [Google Scholar]
  10. Gonwa T. A., Picker L. J., Raff H. V., Goyert S. M., Silver J., Stobo J. D. Antigen-presenting capabilities of human monocytes correlates with their expression of HLA-DS, an Ia determinant distinct from HLA-DR. J Immunol. 1983 Feb;130(2):706–711. [PubMed] [Google Scholar]
  11. Guy K., Van Heyningen V., Cohen B. B., Deane D. L., Steel C. M. Differential expression and serologically distinct subpopulations of human Ia antigens detected with monoclonal antibodies to Ia alpha and beta chains. Eur J Immunol. 1982 Nov;12(11):942–948. doi: 10.1002/eji.1830121109. [DOI] [PubMed] [Google Scholar]
  12. Hunt J. S., King C. R., Jr, Wood G. W. Evaluation of human chorionic trophoblast cells and placental macrophages as stimulators of maternal lymphocyte proliferation in vitro. J Reprod Immunol. 1984 Dec;6(6):377–391. doi: 10.1016/0165-0378(84)90047-0. [DOI] [PubMed] [Google Scholar]
  13. Kabawat S. E., Mostoufi-Zadeh M., Driscoll S. G., Bhan A. K. Implantation site in normal pregnancy. A study with monoclonal antibodies. Am J Pathol. 1985 Jan;118(1):76–84. [PMC free article] [PubMed] [Google Scholar]
  14. Loke Y. W., Eremin O., Ashby J., Day S. Characterization of the phagocytic cells isolated from the human placenta. J Reticuloendothel Soc. 1982 Apr;31(4):317–324. [PubMed] [Google Scholar]
  15. Natali P. G., Russo C., Ng A. K., Nicotra M. R., Apollonj C., Pellegrino M. A., Ferrone S. Ontogeny of human Ia antigens. Cell Immunol. 1982 Nov 1;73(2):385–396. doi: 10.1016/0008-8749(82)90465-8. [DOI] [PubMed] [Google Scholar]
  16. Oksenberg J. R., Mor-Yosef S., Persitz E., Schenker Y., Mozes E., Brautbar C. Antigen-presenting cells in human decidual tissue. Am J Reprod Immunol Microbiol. 1986 Jul;11(3):82–88. doi: 10.1111/j.1600-0897.1986.tb00036.x. [DOI] [PubMed] [Google Scholar]
  17. Redman C. W. HLA-DR antigen on human trophoblast: a review. Am J Reprod Immunol. 1983 Jun;3(4):175–177. doi: 10.1111/j.1600-0897.1983.tb00241.x. [DOI] [PubMed] [Google Scholar]
  18. Sone T., Tsukamoto K., Hirayama K., Nishimura Y., Takenouchi T., Aizawa M., Sasazuki T. Two distinct class II molecules encoded by the genes within HLA-DR subregion of HLA-Dw2 and Dw12 can act as stimulating and restriction molecules. J Immunol. 1985 Aug;135(2):1288–1298. [PubMed] [Google Scholar]
  19. Starkey P. M. Reactivity of human trophoblast with an antibody to the HLA class II antigen, HLA-DP. J Reprod Immunol. 1987 May;11(1):63–70. doi: 10.1016/0165-0378(87)90007-6. [DOI] [PubMed] [Google Scholar]
  20. Sunderland C. A., Naiem M., Mason D. Y., Redman C. W., Stirrat G. M. The expression of major histocompatibility antigens by human chorionic villi. J Reprod Immunol. 1981 Dec;3(6):323–331. doi: 10.1016/0165-0378(81)90048-6. [DOI] [PubMed] [Google Scholar]
  21. Sutton L., Mason D. Y., Redman C. W. HLA-DR positive cells in the human placenta. Immunology. 1983 May;49(1):103–112. [PMC free article] [PubMed] [Google Scholar]
  22. Watson A. J., DeMars R., Trowbridge I. S., Bach F. H. Detection of a novel human class II HLA antigen. 1983 Jul 28-Aug 3Nature. 304(5924):358–361. doi: 10.1038/304358a0. [DOI] [PubMed] [Google Scholar]
  23. Wood G. W. Mononuclear phagocytes in the human placenta. Placenta. 1980 Apr-Jun;1(2):113–123. doi: 10.1016/s0143-4004(80)80019-1. [DOI] [PubMed] [Google Scholar]
  24. van Heyningen V., Guy K., Newman R., Steel C. M. Human MHC class II molecules as differentiation markers. Immunogenetics. 1982;16(5):459–469. doi: 10.1007/BF00372104. [DOI] [PubMed] [Google Scholar]

Articles from Immunology are provided here courtesy of British Society for Immunology

RESOURCES