Skip to main content
California Medicine logoLink to California Medicine
. 1973 Jun;118(6):19–23.

Seminars in Virology: The Mystique of the Herpesviruses

Joseph W St Geme Jr
PMCID: PMC1454965  PMID: 4354670

Abstract

Probing the biologic mystique of the herpesvirus family, we find elements of antigenic similarity, the capacity of virions to persist within our cells in complete form, and the potential at some later time for these virions to undergo renewed replication. A venereal mode of transmission from one host to another may be characteristic of some of these viruses. Similar patterns of illness may be produced by several of the herpesviruses. Within the cellular framework of inflammation and necrosis which infective virus may evoke in the host, there may also reside the capability of neoplastic transformation.

Full text

PDF
19

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Diosi P., Moldovan E., Tomescu N. Latent cytomegalovirus infection in blood donors. Br Med J. 1969 Dec 13;4(5684):660–662. doi: 10.1136/bmj.4.5684.660. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Duff R., Rapp F. Oncogenic transformation of hamster cells after exposure to herpes simplex virus type 2. Nat New Biol. 1971 Sep 8;233(36):48–50. doi: 10.1038/newbio233048a0. [DOI] [PubMed] [Google Scholar]
  3. EVANS A. S. Infectious mononucleosis in University of Wisconsin students. Report of a five-year investigation. Am J Hyg. 1960 May;71:342–362. doi: 10.1093/oxfordjournals.aje.a120118. [DOI] [PubMed] [Google Scholar]
  4. Emanuel I., Kenny G. E. Cytomegalic inclusion disease of infancy. Pediatrics. 1966 Dec;38(6):957–965. [PubMed] [Google Scholar]
  5. Evans A. S., Niederman J. C., McCollum R. W. Seroepidemiologic studies of infectious mononucleosis with EB virus. N Engl J Med. 1968 Nov 21;279(21):1121–1127. doi: 10.1056/NEJM196811212792101. [DOI] [PubMed] [Google Scholar]
  6. Hanshaw J. B. Congenital cytomegalovirus infection: a fifteen year perspective. J Infect Dis. 1971 May;123(5):555–561. doi: 10.1093/infdis/123.5.555. [DOI] [PubMed] [Google Scholar]
  7. Hanshaw J. B. Cytomegalovirus complement-fixing antibody in microcephaly. N Engl J Med. 1966 Sep 1;275(9):476–479. doi: 10.1056/NEJM196609012750905. [DOI] [PubMed] [Google Scholar]
  8. Hanshaw J. B., Niederman J. C., Chessin L. N. Cytomegalovirus macroglobulin in cell-associated herpesvirus infections. J Infect Dis. 1972 Mar;125(3):304–306. doi: 10.1093/infdis/125.3.304. [DOI] [PubMed] [Google Scholar]
  9. Henle W., Henle G., Scriba M., Joyner C. R., Harrison F. S., Jr, Von Essen R., Paloheimo J., Klemola E. Antibody responses to the Epstein-Barr virus and cytomegaloviruses after open-heart and other surgery. N Engl J Med. 1970 May 7;282(19):1068–1074. doi: 10.1056/NEJM197005072821904. [DOI] [PubMed] [Google Scholar]
  10. Klemola E., Käriäinen L. Cytomegalovirus as a possible cause of a disease resembling infectious mononucleosis. Br Med J. 1965 Nov 6;2(5470):1099–1102. doi: 10.1136/bmj.2.5470.1099. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Lang D. J. The association of indirect inguinal hernia with congenital cytomegalic inclusion disease. Pediatrics. 1966 Nov;38(5):913–916. [PubMed] [Google Scholar]
  12. MERCER R. D., LUSE S., GUYTON D. H. Clinical diagnosis of generalized cytomegalic inclusion disease. Pediatrics. 1953 May;11(5):502–514. [PubMed] [Google Scholar]
  13. Montgomery R., Youngblood L., Medearis D. N., Jr Recovery of cytomegalovirus from the cervix in pregnancy. Pediatrics. 1972 Apr;49(4):524–531. [PubMed] [Google Scholar]
  14. Nahmias A. J., Alford C. A., Korones S. B. Infection of the newborn with herpesvirus hominis. Adv Pediatr. 1970;17:185–226. [PubMed] [Google Scholar]
  15. Nahmias A. J., Josey W. E., Naib Z. M., Luce C. F., Guest B. A. Antibodies to Herpesvirus hominis types 1 and 2 in humans. II. Women with cervical cancer. Am J Epidemiol. 1970 Jun;91(6):547–552. doi: 10.1093/oxfordjournals.aje.a121166. [DOI] [PubMed] [Google Scholar]
  16. Numazaki Y., Yano N., Morizuka T., Takai S., Ishida N. Primary infection with human cytomegalovirus: virus isolation from healthy infants and pregnant women. Am J Epidemiol. 1970 Apr;91(4):410–417. doi: 10.1093/oxfordjournals.aje.a121151. [DOI] [PubMed] [Google Scholar]
  17. Prince A. M., Szmuness W., Millian S. J., David D. S. A serologic study of cytomegalovirus infections associated with blood transfusions. N Engl J Med. 1971 May 20;284(20):1125–1131. doi: 10.1056/NEJM197105202842004. [DOI] [PubMed] [Google Scholar]
  18. Rawls W. E., Tompkins W. A., Figueroa M. E., Melnick J. L. Herpesvirus type 2: association with carcinoma of the cervix. Science. 1968 Sep 20;161(3847):1255–1256. doi: 10.1126/science.161.3847.1255. [DOI] [PubMed] [Google Scholar]
  19. Rawls W. E., Tompkins W. A., Melnick J. L. The association of herpesvirus type 2 and carcinoma of the uterine cervix. Am J Epidemiol. 1969 May;89(5):547–554. doi: 10.1093/oxfordjournals.aje.a120967. [DOI] [PubMed] [Google Scholar]
  20. St Geme J. W., Jr, Brumbaugh J. L. Comparative susceptibility of neonatal rabbit skin to herpes simplex virus in vitro. Proc Soc Exp Biol Med. 1967 Oct;126(1):285–289. doi: 10.3181/00379727-126-32426. [DOI] [PubMed] [Google Scholar]
  21. Starr J. G., Bart R. D., Jr, Gold E. Inapparent congenital cytomegalovirus infection. Clinical and epidemiologic characteristics in early infancy. N Engl J Med. 1970 May 7;282(19):1075–1078. doi: 10.1056/NEJM197005072821905. [DOI] [PubMed] [Google Scholar]
  22. Stevens J. G., Cook M. L. Latent herpes simplex virus in spinal ganglia of mice. Science. 1971 Aug 27;173(3999):843–845. doi: 10.1126/science.173.3999.843. [DOI] [PubMed] [Google Scholar]
  23. Tischendorf P., Shramek G. J., Balagtas R. C., Deinhardt F., Knospe W. H., Noble G. R., Maynard J. E. Development and persistence of immunity to Epstein-Barr virus in man. J Infect Dis. 1970 Nov;122(5):401–409. doi: 10.1093/infdis/122.5.401. [DOI] [PubMed] [Google Scholar]
  24. WELLER T. H., HANSHAW J. B. Virologic and clinical observations on cytomegalic inclusion disease. N Engl J Med. 1962 Jun 14;266:1233–1244. doi: 10.1056/NEJM196206142662401. [DOI] [PubMed] [Google Scholar]

Articles from California Medicine are provided here courtesy of BMJ Publishing Group

RESOURCES