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. 1970 May;18(5):769–774.

Studies on the asymmetrically attached oligosaccharide of rabbit immunoglobulin-G

II. On the biological function of the C2-oligosaccharide

W A Hinrichs, D G Smyth
PMCID: PMC1455587  PMID: 5420727

Abstract

Rabbit IgG consists of two populations of molecules, one containing and the other lacking the C2-oligosaccharide. Comparison of the properties of the two molecular species has been used to obtain an understanding of the functional role of the carbohydrate moiety. The C2-oligosaccharide does not appear to be involved in secretion of IgG from the biosynthetic cell; it does not contribute to allotypic specificities 1/4, 2/4, and 3/4; it affords the IgG molecule a degree of protection from biological degradation. The presence of the C2-oligosaccharide in an IgG molecule mediates against transfer of the molecule across the placental membrane. Both C2- containing and C2- free IgG molecules are present in purified antibody.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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