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. 1970 Nov;19(5):767–769.

The role of the sixth component of complement in the rejection of kidney xenografts

J E Mejía-Laguna, M García-Cornejo, F Lopez-Soriano, C E Biro
PMCID: PMC1455643  PMID: 4922033

Abstract

The time of rejection of dog kidney grafts in normal and in C6-deficient rabbits was not significantly different. It is concluded that the last four components of complement are not involved in this form of violent xenograft rejection. The requirement for the first components may be explained by polymorphonuclear leucocyte chemotaxis, since these cells were found in the glomeruli of rejected kidneys.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Biro C. E. The role of the sixth component of complement in some types of hypersensitivity. Immunology. 1966 Jun;10(6):563–565. [PMC free article] [PubMed] [Google Scholar]
  2. Bokisch V. A., Müller-Eberhard H. J., Cochrane C. G. Isolation of a fragment (C3a) of the third component of human complement containing anaphylatoxin and chemotactic activity and description of an anaphylatoxin inactivator of human serum. J Exp Med. 1969 May 1;129(5):1109–1130. doi: 10.1084/jem.129.5.1109. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Feldman J. D., Lee S. Renal homotransplantation in rats. I. Allogeneic recipients. J Exp Med. 1967 Nov 1;126(5):783–794. doi: 10.1084/jem.126.5.783. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Jensen J. A. A specific inactivator of mammalian C'4 isolated from nurse shark (Ginglymostoma cirratum) serum. J Exp Med. 1969 Aug 1;130(2):217–241. doi: 10.1084/jem.130.2.217. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Linn B. S., Jennsen J. A., Portal P., Snyder G. B. Renal xenograft prolongation by suppression of natural antibody. J Surg Res. 1968 May;8(5):211–213. doi: 10.1016/0022-4804(68)90088-7. [DOI] [PubMed] [Google Scholar]
  6. Nelson R. A., Jr A new concept of immunosuppression in hypersensitivity reactions and in transplantation immunity. Surv Ophthalmol. 1966 Aug;11(4):498–505. [PubMed] [Google Scholar]
  7. Ward P. A., Cochrane C. G., Muller-Eberhard H. J. Further studies on the chemotactic factor of complement and its formation in vivo. Immunology. 1966 Aug;11(2):141–153. [PMC free article] [PubMed] [Google Scholar]

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