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. 1970 Dec;19(6):891–894.

The immunoglobulin class of autoantibody-containing cells in the gastric mucosa

Sonia Baur, Nancy Koo, K B Taylor
PMCID: PMC1455669  PMID: 4922562

Abstract

Autoantibody to Castle's intrinsic factor in mucosal plasma cells in gastric biopsies of patients with pernicious anaemia has been shown to be of the IgG type, using a double-labelling technique. The role of IgG immunoglobulins compared with that of IgA immunoglobulins in the immune response to autoantigens and to foreign proteins in the gastrointestinal tract is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baur S., Fisher J. M., Strickland R. G., Taylor K. B. Autoantibody-containing cells in the gastric mucosa in pernicious anaemia. Lancet. 1968 Oct 26;2(7574):887–894. doi: 10.1016/s0140-6736(68)91054-4. [DOI] [PubMed] [Google Scholar]
  2. Crabbé P. A., Heremans J. F. The distribution of immunoglobulin-containing cells along the human gastrointestinal tract. Gastroenterology. 1966 Sep;51(3):305–316. [PubMed] [Google Scholar]
  3. Crabbé P. A., Nash D. R., Bazin H., Eyssen D. V., Heremans J. F. Antibodies of the IgA type in intestinal plasma cells of germfree mice after oral or parenteral immunization with ferritin. J Exp Med. 1969 Oct 1;130(4):723–744. doi: 10.1084/jem.130.4.723. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Gelzayd E. A., Kraft S. C., Fitch F. W., Kirsner J. B. Distribution of immunoglobulins in human rectal mucosa. II. Ulcerative colitis and abnormal mucosal control subjects. Gastroenterology. 1968 Mar;54(3):341–347. [PubMed] [Google Scholar]
  5. Gelzayd E. A., Kraft S. C., Kirsner J. B. Distribution of immunoglobulins in human rectal mucosa. I. Normal control subjects. Gastroenterology. 1968 Mar;54(3):334–340. [PubMed] [Google Scholar]
  6. McDevitt H. O., Askonas B. A., Humphrey J. H., Schechter I., Sela M. The localization of antigen in relation to specific antibody-producing cells. I. Use of a synthetic polypeptide [(T,G)-A--L] labelled with iodine-125. Immunology. 1966 Oct;11(4):337–351. [PMC free article] [PubMed] [Google Scholar]
  7. Odgers R. J., Wangel A. G. Abnormalities in IgA-containing mononuclear cells in the gastric lesion of pernicious anaemia. Lancet. 1968 Oct 19;2(7573):846–849. doi: 10.1016/s0140-6736(68)91001-5. [DOI] [PubMed] [Google Scholar]
  8. RUBIN W., FAUCI A. S., MARVIN S. F., SLEISENGER M. H., JEFRIES G. H. IMMUNOFLUORESCENT STUDIES IN ADULT CELIAC DISEASE. J Clin Invest. 1965 Mar;44:475–485. doi: 10.1172/JCI105161. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Samloff I. M., Barnett E. V. Identification of intrinsic factor autoantibody and intrinsic factor in man by radioimmunodiffusion and radioimmunoelectrophoresis. J Immunol. 1965 Sep;95(3):536–541. [PubMed] [Google Scholar]
  10. TOMASI T. B., Jr, TAN E. M., SOLOMON A., PRENDERGAST R. A. CHARACTERISTICS OF AN IMMUNE SYSTEM COMMON TO CERTAIN EXTERNAL SECRETIONS. J Exp Med. 1965 Jan 1;121:101–124. doi: 10.1084/jem.121.1.101. [DOI] [PMC free article] [PubMed] [Google Scholar]

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