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. 1970 Jun;18(6):909–920.

Intestinal secretion of immunoglobulins and antibodies to Escherichia coli in the pig

P Porter, D E Noakes, W D Allen
PMCID: PMC1455724  PMID: 4193669

Abstract

Immunoglobulins and antibodies against Escherichia coli 0141 have been studied in porcine intestinal secretions obtained from Thiry Vella loops prepared in the mid jejunum of 4 animals.

The molecular size of the secreted immunoglobulins were investigated by gel filtration and sucrose density gradient ultra-centrifugation. Intestinal IgM was found to have 7S characteristics and intestinal IgA mainly 11S characteristics similar to secretory IgA isolated from porcine milk.

Immune inhibition studies with rabbit anti-IgA-globulin serum produced complete elimination of E. coli 0141 antibodies detected by direct haemagglutination. In one animal incomplete antibody assayed by antiglobulin haemagglutination was identified in fractions associated with IgM and IgG.

Immunofluorescent studies were made to correlate immunoglobulins in the small intestinal tissue with weaning.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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