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. 1971 Mar;20(3):269–275.

The effect of anti-lymphocytic antibody on the development of experimental thyroiditis in rats induced by the intra-lymph node injection of rat thyroglobin in Freund's complete adjuvant

J R Kalden, K James
PMCID: PMC1455834  PMID: 5551352

Abstract

Anti-lymphocytic IgG given immediately after the injection of thyroglobulin in Freund's complete adjuvant suppressed the development of cellular and humoral immune reactions to thyroglobulin in rats immunized into a hind footpad but failed to exert a significant effect when the antigen was injected into two cervical lymph nodes. However, treatment with anti-lymphocytic IgG for 3 days prior to intra-lymph node immunization with thyroglobulin prevented the development of cellular and humoral immune responses to this antigen.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baroni C. D., Kimball J. W., Ward E. N., Wagar R. D. A histological and immunological study of the effect of rabbit anti-mouse lymphocyte serum in BALB-c mice. Transplantation. 1969 May;7(5):303–314. doi: 10.1097/00007890-196905000-00001. [DOI] [PubMed] [Google Scholar]
  2. Berenbaum M. C. Time-dependent immunosuppressive effects of anti-thymocyte serum. Nature. 1967 Sep 30;215(5109):1481–1482. doi: 10.1038/2151481a0. [DOI] [PubMed] [Google Scholar]
  3. Clunie G. J., Nolan B., James K., Watt J. G., Woodruff M. F. Prolongation of canine renal allograft survival with antilymphocytic serum. Transplantation. 1968 May;6(3):459–467. doi: 10.1097/00007890-196805000-00017. [DOI] [PubMed] [Google Scholar]
  4. Currey H. L., Ziff M. Suppression of adjuvant disease in the rat by heterologous antilymphocyte globulin. J Exp Med. 1968 Jan 1;127(1):185–203. doi: 10.1084/jem.127.1.185. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Denman A. M. Anti-lymphocytic antibody and autoimmune disease: a review. Clin Exp Immunol. 1969 Sep;5(3):217–249. [PMC free article] [PubMed] [Google Scholar]
  6. Denman A. M., Denman E. J., Embling P. H. Changes in the life-span of circulating small lymphocytes in mice after treatment with anti-lymphocyte globulin. Lancet. 1968 Feb 17;1(7538):321–325. doi: 10.1016/s0140-6736(68)90791-5. [DOI] [PubMed] [Google Scholar]
  7. Denman A. M., Frenkel E. P. Mode of action of anti-lymphocyte globulin. II. Changes in the lymphoid cell population in rats treated with anti-lymphocyte globulin. Immunology. 1968 Jan;14(1):115–126. [PMC free article] [PubMed] [Google Scholar]
  8. Field E. J. Antilymphocytic serum in experimental allergic encephalomyelitis. Br Med J. 1969 Sep 27;3(5673):758–760. doi: 10.1136/bmj.3.5673.758. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. James K. Some factors influencing the ability of anti-lymphocytic antibody to suppress humoral antibody formation. Clin Exp Immunol. 1967 Nov;2(6):685–690. [PMC free article] [PubMed] [Google Scholar]
  10. Kalden J., James K. K., Williamson W. G., Irvine W. J. The suppression of experimental thyroiditis in the rat by heterologous anti-lymphocyte globulin. Clin Exp Immunol. 1968 Nov;3(9):973–981. [PMC free article] [PubMed] [Google Scholar]
  11. Kalden J., James K., Williamson W. G., Irvine W. J. The effect of anti-lymphocytic IgG on estab- lished autoallergic thyroiditis in rats. Clin Exp Immunol. 1969 Dec;5(6):597–606. [PMC free article] [PubMed] [Google Scholar]
  12. Kalden J., James K., Williamson W. G., Irvine W. J. The effect of anti-lymphocytic IgG on estab- lished autoallergic thyroiditis in rats. Clin Exp Immunol. 1969 Dec;5(6):597–606. [PMC free article] [PubMed] [Google Scholar]
  13. Leibowitz S., Lessof M. H., Kennedy L. A. The effect of anti-lymphocyte serum on experimental allergic encephalomyelitis in the guinea-pig. Clin Exp Immunol. 1968 Oct;3(8):753–760. [PMC free article] [PubMed] [Google Scholar]
  14. Leuchars E., Wallis V. J., Davies A. J. Mode of action for anti-lymphocyte serum. Nature. 1968 Sep 28;219(5161):1325–1328. doi: 10.1038/2191325a0. [DOI] [PubMed] [Google Scholar]
  15. Levey R. H., Medawar P. B. Further experiments on the action of antilymphocytic antiserum. Proc Natl Acad Sci U S A. 1967 Aug;58(2):470–477. doi: 10.1073/pnas.58.2.470. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Martin W. J., Miller J. F. Cell to cell interaction in the immune response. IV. Site of action of antilymphocyte globulin. J Exp Med. 1968 Oct 1;128(4):855–874. doi: 10.1084/jem.128.4.855. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Martin W. J., Miller J. F. Site of action of antilymphocyte globulin. Lancet. 1967 Dec 16;2(7529):1285–1287. doi: 10.1016/s0140-6736(67)90395-9. [DOI] [PubMed] [Google Scholar]
  18. Mates G. P., Shulman S. Studies on thyroid proteins. 3. Precipitating activity of autoimmune and heteroimmune antisera with human thyroglobulin. Immunochemistry. 1967 Sep;4(5):319–330. doi: 10.1016/0019-2791(67)90115-2. [DOI] [PubMed] [Google Scholar]
  19. Monaco A. P., Wood M. L., Gray J. G., Russell P. S. Studies on heterologous anti-lymphocyte serum in mice. II. Effect on the immune response. J Immunol. 1966 Feb;96(2):229–238. [PubMed] [Google Scholar]
  20. Möller G., Zukoski C. F. Heterologous antilymphocyte serum: differential effect on antigen-sensitive and antibody-producing cells. Surgery. 1968 Jul;64(1):39–47. [PubMed] [Google Scholar]
  21. Turk J. L., Willoughby D. A. An analysis of the multiplicity of the effects of antilymphocyte serum. A comparison with the action of other immunosuppressive agents in the cell-mediated immune response and non-specific inflammation. Antibiot Chemother. 1969;15:267–294. doi: 10.1159/000386786. [DOI] [PubMed] [Google Scholar]
  22. Turk J. L., Willoughby D. A. Central and peripheral effects of anti-lymphocyte sera. Lancet. 1967 Feb 4;1(7484):249–251. doi: 10.1016/s0140-6736(67)91307-4. [DOI] [PubMed] [Google Scholar]

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