Abstract
Mice of several strains were immunized with DNP-haemocyanin either with Al(OH)3 or with Freund's complete adjuvant. Antibodies of immunoglobulin type γ2 and γM were detected by passive haemolysis, γ2a antibodies by PCA in guinea-pigs, γ1 antibodies by PCA in mice using 2 hours of SP, and reaginic antibodies by PCA in mice using 72 hours of SP. Three of the six strains tested produced reaginic antibodies, i.e. SWR/J, C57BL/6J and A/HeJ, but only when Al(OH)3 was used as adjuvant. All six strains produced γ1 antibodies. Reaginic antibodies were separated by chromatography on DEAE-cellulose column.
Full text
PDF









Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BINAGHI R. A., BENACERRAF B. THE PRODUCTION OF ANAPHYLACTIC ANTIBODY IN THE RAT. J Immunol. 1964 Jun;92:920–926. [PubMed] [Google Scholar]
- BOYDEN S. V. The adsorption of proteins on erythrocytes treated with tannic acid and subsequent hemagglutination by antiprotein sera. J Exp Med. 1951 Feb;93(2):107–120. doi: 10.1084/jem.93.2.107. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Barth W. F., Fahey J. L. Heterologous and homologous skin-sensitizing activity of mouse 7S gamma 1- and 7S gamma 2-globulins. Nature. 1965 May 15;206(985):730–731. doi: 10.1038/206730a0. [DOI] [PubMed] [Google Scholar]
- Barth W. F., McLaughlin C. L., Fahey J. L. The immunoglobulins of mice. VI. Response to immunization. J Immunol. 1965 Nov;95(5):781–790. [PubMed] [Google Scholar]
- Coe J. E. 7Sgamma-1 and 7Sgamma-2 antibody response in the mouse. I. Influence of strain, antigen and adjuvant. J Immunol. 1966 Apr;96(4):744–753. [PubMed] [Google Scholar]
- EDELMAN G. M., KUNKEL H. G., FRANKLIN E. C. Interaction of the rheumatoid factor with antigen-antibody complexes and aggregated gamma globulin. J Exp Med. 1958 Jul 1;108(1):105–120. doi: 10.1084/jem.108.1.105. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HERZENBERG L. A., WARNER N. L., HERZENBERG L. A. IMMUNOGLOBULIN ISOANTIGENS (ALLOTYPES) IN THE MOUSE. I. GENETICS AND CROSS-REACTIONS OF THE 7S GAMMA-2A-ISOANTIGENS CONTROLLED BY ALLELES AT THE IG-1 LOCUS. J Exp Med. 1965 Mar 1;121:415–438. doi: 10.1084/jem.121.3.415. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MOTA I. THE MECHANISM OF ANAPHYLAXIS. I. PRODUCTION AND BIOLOGICAL PROPERTIES OF 'MAST CELL SENSITIZING' ANTIBODY. Immunology. 1964 Nov;7:681–699. [PMC free article] [PubMed] [Google Scholar]
- McCamish J. A heat-labile skin sensitizing activity of mouse serum. Nature. 1967 Jun 17;214(5094):1228–1229. doi: 10.1038/2141228a0. [DOI] [PubMed] [Google Scholar]
- Mota I. Biological characterization of mouse 'early' antibodies. Immunology. 1967 Mar;12(3):343–348. [PMC free article] [PubMed] [Google Scholar]
- Mota I., Peixoto J. M. A skin-sensitizing and thermolabile antibody in the mouse. Life Sci. 1966 Sep;5(18):1723–1728. doi: 10.1016/0024-3205(66)90108-1. [DOI] [PubMed] [Google Scholar]
- NUSSENZWEIG R. S., MERRYMAN C., BENACERRAF B. ELECTROPHORETIC SEPARATION AND PROPERTIES OF MOUSE ANTIHAPTEN ANTIBODIES INVOLVED IN PASSIVE CUTANEOUS ANAPHYLAXIS AND PASSIVE HEMOLYSIS. J Exp Med. 1964 Aug 1;120:315–328. doi: 10.1084/jem.120.2.315. [DOI] [PMC free article] [PubMed] [Google Scholar]
- OGILVIE B. M. REAGIN-LIKE ANTIBODIES IN ANIMALS IMMUNE TO HELMINTH PARASITES. Nature. 1964 Oct 3;204:91–92. doi: 10.1038/204091a0. [DOI] [PubMed] [Google Scholar]
- OVARY Z., BARTH W. F., FAHEY J. L. THE IMMUNOGLOBULINS OF MICE. 3. SKIN SENSITIZING ACTIVITY OF MOUSE IMMUNOGLOBULINS. J Immunol. 1965 Mar;94:410–415. [PubMed] [Google Scholar]
- OVARY Z., BENACERRAF B. IMMUNOLOGICAL SPECIFICITY OF THE SECONDARY RESPONSE WITH DINITROPHENYLATED PROTEINS. Proc Soc Exp Biol Med. 1963 Oct;114:72–76. doi: 10.3181/00379727-114-28589. [DOI] [PubMed] [Google Scholar]
- Ogilvie B. M. Reagin-like antibodies in rats infected with the nematode parasite Nippostrongylus brasiliensis. Immunology. 1967 Feb;12(2):113–131. [PMC free article] [PubMed] [Google Scholar]
- Spitz E., Ovary Z. Quantitative studies on gamma-2 anti-dinitrophenyl antibodies. Proc Soc Exp Biol Med. 1966 May;122(1):253–257. doi: 10.3181/00379727-122-31103. [DOI] [PubMed] [Google Scholar]
- Vaz N. M., Ovary Z. Passive anaphylaxis in mice with gamma-G antibodies. I. PCA and RPCA reactions with homologous and heterologous antibodies. J Immunol. 1968 Jan;100(1):169–174. [PubMed] [Google Scholar]
- Warner N. L., Vaz N. M., Ovary Z. Immunoglobulin classes in antibody responses in mice. I. Analysis by biological properties. Immunology. 1968 May;14(5):725–734. [PMC free article] [PubMed] [Google Scholar]
- Wilson R. J., Bloch K. J. Homocytotropic antibody response in the rat infected with the nematode, Nippostrongylus brasiliensis. II. Characteristics of the immune response. J Immunol. 1968 Mar;100(3):622–628. [PubMed] [Google Scholar]
- Zvaifler N. J., Becker E. L. Rabbit anaphylactic antibody. J Exp Med. 1966 May 1;123(5):935–950. doi: 10.1084/jem.123.5.935. [DOI] [PMC free article] [PubMed] [Google Scholar]