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. 1971 Apr;20(4):523–531.

The pathogenesis of autoimmunity in New Zealand mice

III. Factors influencing the formation of anti-nucleic acid antibodies

Alfred D Steinberg, Theodore Pincus, Norman Talal
PMCID: PMC1455989  PMID: 5553068

Abstract

The synthetic double stranded ribonucleic acids rI·rC and rA·rU were found to be immunogenic in normal mice when given without a protein carrier in Freund's complete adjuvant. When RNA was given without adjuvant, antibody could be detected only in New Zealand mice. Greater quantities of antibody were produced by females than males as in spontaneous disease. Sexual alteration did not alter this pattern.

Spontaneous antibodies to RNA appeared before antibodies to DNA in NZB/NZW mice, suggesting that a naturally occurring double stranded RNA may be a major factor in the spontaneous production of anti-nucleic acid antibodies.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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