Abstract
Immunological tolerance to synthetic polypeptides containing poly-L-proline has been induced in guinea-pigs by appropriate injections. The recovery from tolerance without further immunization has been followed by repeated skin testing. The tolerance involved both humoral antibody production and the development of delayed hypersensitivity. The results were interpreted on the basis of two hypotheses.
(1) The avidity between antigen and antibody is a function of both the accuracy of fit and the extent over which the fitting takes place.
(2) Antibody produced in animals showing partial tolerance differs from antibody in non-tolerant animals by a less perfect fit.
Evidence is also presented that immunization with antigen in the presence of antibody to some only of its determinants favours an immune response to the remaining determinants.
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Selected References
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