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. 1997 Jan;90(1):7–13. doi: 10.1046/j.1365-2567.1997.00127.x

Recovery from retrovirus-induced immune suppression in BDP/J mice: dominance of the "regressor' phenotype.

G L Gilmore 1
PMCID: PMC1456726  PMID: 9038706

Abstract

Murine acquired immune deficiency syndrome (MAIDS) is an immunosuppressive disease of mice induced by infection with the LP-BM5 murine leukemia virus (MuLV) retrovirus isolate. Certain inbred strains of mice are resistant to disease, but F1 crosses between sensitive and resistant strains are predominantly sensitive to MAIDS. One inbred strain, BDP, demonstrates a novel disease phenotype, recovery of immune function after a period of profound immune suppression. This trait is genetically dominant in crosses between BDP and either sensitive or resistant strains. The 'regressor' phenotype reveals the existence of a mechanism for recovery from immunosuppressive retrovirus infections, which may be of import in developing therapies for AIDS patients.

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Selected References

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  1. Aziz D. C., Hanna Z., Jolicoeur P. Severe immunodeficiency disease induced by a defective murine leukaemia virus. Nature. 1989 Apr 6;338(6215):505–508. doi: 10.1038/338505a0. [DOI] [PubMed] [Google Scholar]
  2. Chattopadhyay S. K., Morse H. C., 3rd, Makino M., Ruscetti S. K., Hartley J. W. Defective virus is associated with induction of murine retrovirus-induced immunodeficiency syndrome. Proc Natl Acad Sci U S A. 1989 May;86(10):3862–3866. doi: 10.1073/pnas.86.10.3862. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Frankel W. N., Stoye J. P., Taylor B. A., Coffin J. M. Genetic analysis of endogenous xenotropic murine leukemia viruses: association with two common mouse mutations and the viral restriction locus Fv-1. J Virol. 1989 Apr;63(4):1763–1774. doi: 10.1128/jvi.63.4.1763-1774.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Fultz P. N. Nonhuman primate models for AIDS. Clin Infect Dis. 1993 Aug;17 (Suppl 1):S230–S235. doi: 10.1093/clinids/17.supplement_1.s230. [DOI] [PubMed] [Google Scholar]
  5. Gilmore G. L. Adoptive transfer of resistance to murine retrovirus-induced immune suppression. Cell Immunol. 1996 Apr 10;169(1):24–29. doi: 10.1006/cimm.1996.0086. [DOI] [PubMed] [Google Scholar]
  6. Gilmore G. L., Cowing C., Mosier D. E. LP-BM5 murine retrovirus-induced immunodeficiency disease in allogeneic SCID chimeric mice. Inability to recognize a putative viral superantigen does not prevent induction of disease. J Immunol. 1993 Jan 1;150(1):185–189. [PubMed] [Google Scholar]
  7. Hartley J. W., Fredrickson T. N., Yetter R. A., Makino M., Morse H. C., 3rd Retrovirus-induced murine acquired immunodeficiency syndrome: natural history of infection and differing susceptibility of inbred mouse strains. J Virol. 1989 Mar;63(3):1223–1231. doi: 10.1128/jvi.63.3.1223-1231.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Huang M., Jolicoeur P. Myristylation of Pr60gag of the murine AIDS-defective virus is required to induce disease and notably for the expansion of its target cells. J Virol. 1994 Sep;68(9):5648–5655. doi: 10.1128/jvi.68.9.5648-5655.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Huang M., Simard C., Kay D. G., Jolicoeur P. The majority of cells infected with the defective murine AIDS virus belong to the B-cell lineage. J Virol. 1991 Dec;65(12):6562–6571. doi: 10.1128/jvi.65.12.6562-6571.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Huang M., Takac M., Kozak C. A., Jolicoeur P. The murine AIDS defective provirus acts as an insertional mutagen in its infected target B cells. J Virol. 1995 Jul;69(7):4069–4078. doi: 10.1128/jvi.69.7.4069-4078.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Klinken S. P., Fredrickson T. N., Hartley J. W., Yetter R. A., Morse H. C., 3rd Evolution of B cell lineage lymphomas in mice with a retrovirus-induced immunodeficiency syndrome, MAIDS. J Immunol. 1988 Feb 15;140(4):1123–1131. [PubMed] [Google Scholar]
  12. Laurence J., Astrin S. M. Human immunodeficiency virus induction of malignant transformation in human B lymphocytes. Proc Natl Acad Sci U S A. 1991 Sep 1;88(17):7635–7639. doi: 10.1073/pnas.88.17.7635. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Li Q. X., Fan H. Bone marrow depletion by 89Sr complements a preleukemic defect in a long terminal repeat variant of Moloney murine leukemia virus. J Virol. 1991 Aug;65(8):4442–4448. doi: 10.1128/jvi.65.8.4442-4448.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Makino M., Davidson W. F., Fredrickson T. N., Hartley J. W., Morse H. C., 3rd Effects of non-MHC loci on resistance to retrovirus-induced immunodeficiency in mice. Immunogenetics. 1991;33(5-6):345–351. doi: 10.1007/BF00216693. [DOI] [PubMed] [Google Scholar]
  15. Marcu K. B., Harris L. J., Stanton L. W., Erikson J., Watt R., Croce C. M. Transcriptionally active c-myc oncogene is contained within NIARD, a DNA sequence associated with chromosome translocations in B-cell neoplasia. Proc Natl Acad Sci U S A. 1983 Jan;80(2):519–523. doi: 10.1073/pnas.80.2.519. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Mosier D. E., Yetter R. A., Morse H. C., 3rd Retroviral induction of acute lymphoproliferative disease and profound immunosuppression in adult C57BL/6 mice. J Exp Med. 1985 Apr 1;161(4):766–784. doi: 10.1084/jem.161.4.766. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Penn I. The occurrence of malignant tumors in immunosuppressed states. Prog Allergy. 1986;37:259–300. doi: 10.1159/000318448. [DOI] [PubMed] [Google Scholar]
  18. Rowe W. P., Pugh W. E., Hartley J. W. Plaque assay techniques for murine leukemia viruses. Virology. 1970 Dec;42(4):1136–1139. doi: 10.1016/0042-6822(70)90362-4. [DOI] [PubMed] [Google Scholar]
  19. Storer J. B. Longevity and gross pathology at death in 22 inbred mouse strains. J Gerontol. 1966 Jul;21(3):404–409. doi: 10.1093/geronj/21.3.404. [DOI] [PubMed] [Google Scholar]
  20. Vittecoq D., Mattlinger B., Barre-Sinoussi F., Courouce A. M., Rouzioux C., Doinel C., Bary M., Viard J. P., Bach J. F., Rouger P. Passive immunotherapy in AIDS: a randomized trial of serial human immunodeficiency virus-positive transfusions of plasma rich in p24 antibodies versus transfusions of seronegative plasma. J Infect Dis. 1992 Feb;165(2):364–368. doi: 10.1093/infdis/165.2.364. [DOI] [PubMed] [Google Scholar]

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