TABLE 4.
Impact of treating half-sibs as unrelated on two nonparametric tests: single-locus tests for Hardy-Weinberg Disequilibrium and nonhomogeneity of haplotype frequency profiles for case control data in a neutral genomic region
| Single-locus analysis for Hardy-Weinberg disequilibriuma
|
Association test using haplotype frequency estimates
|
||||
|---|---|---|---|---|---|
| Family size | χ2 (1) | SD | χ2 (8) | SD | |
| IL8E | 1 | 1.69 | 2.23 | 9.32 | 4.05 |
| 5 | 1.71 | 1.87 | 14.53* | 6.57 | |
| 10 | 1.67 | 1.74 | 18.78** | 9.22 | |
| 25 | 2.17 | 2.42 | 26.17*** | 16.37 | |
| 50 | 3.55* | 4.27 | — | — | |
| APOE2 | 1 | 2.47 | 2.05 | 9.37 | 4.12 |
| 5 | 2.29 | 1.99 | 14.76* | 7.09 | |
| 10 | 2.24 | 1.87 | 21.35** | 9.69 | |
| 25 | 2.79 | 2.61 | 35.73*** | 17.91 | |
| 50 | 4.50** | 4.42 | — | — | |
| APOE1 | 1 | 2.43 | 2.11 | 12.51 | 4.66 |
| 5 | 2.43 | 1.99 | 21.41* | 7.47 | |
| 10 | 2.36 | 2.00 | 27.66*** | 12.24 | |
| 25 | 2.99 | 2.77 | 47.68*** | 19.77 | |
| 50 | 5.58** | 4.95 | — | — | |
*Significance at 90%; **significance at 95%; ***significance at 99%. Numbers of loci are in parentheses.
a
For each replicate, the test statistic for the locus exhibiting the highest disequilbirum was used.