Figure 1.

Genome-wide synthetic interactions involving TAF9. Genes for transcription factors are classified into three major groups: Mediator, chromatin-modifying complexes, and regulators of transcription elongation. Yellow ovals denote sets of genes that encode transcription factors that have been demonstrated to biochemically associate with TAFs (see text). Genes marked in red indicate strong genetic interactions; those marked in blue indicate conditional synthetic interactions. Underlined genes are present in multiple categories. Asterisks denote two essential genes identified by a conventional synthetic lethality screen. Solid lines denote functional connections involving specific transcription factors associated with particular cellular processes (see text).