Abstract
This study was performed to determine whether the removal of submandibular gland (SG) of mice influences the delayed-hypersensitivity (DH) response. The removal of the SG increased the weights of thymus and spleen and enhanced DH response, only in males and not in females. The injection of crude extract of male mouse SG returned the enhanced DH response of SG-ectomized males to the normal level whereas the injections of crude extracts of female or castrated male mouse SG was not affected. These results suggested that SG of male mice contains an endocrine factor(s) to regulate DH response.
Full text
PDF



Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Asherson G. L., Ptak W. Contact and delayed hypersensitivity in the mouse. I. Active sensitization and passive transfer. Immunology. 1968 Sep;15(3):405–416. [PMC free article] [PubMed] [Google Scholar]
- Bhoola K. D., Dorey G., Jones C. W. The influence of androgens on enzymes (chymotrypsin-and trypsin-like proteases, renin, kallikrein and amylase) and on cellular structure of the mouse submaxillary gland. J Physiol. 1973 Dec;235(2):503–522. doi: 10.1113/jphysiol.1973.sp010400. [DOI] [PMC free article] [PubMed] [Google Scholar]
- COHEN S. Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal. J Biol Chem. 1962 May;237:1555–1562. [PubMed] [Google Scholar]
- Hosoi K., Nakamura T., Ueha T. Effect of testosterone on the amount of serous-like granules in convoluted tubular cells of mouse submandibular glands. J Biochem. 1977 Mar;81(3):739–748. doi: 10.1093/oxfordjournals.jbchem.a131512. [DOI] [PubMed] [Google Scholar]
- Kongshavn P. A., Bliss J. Q. Effect of mouse submandibular gland extracts on survival of H-2 incompatible skin allografts. Immunology. 1970 Aug;19(2):363–367. [PMC free article] [PubMed] [Google Scholar]
- LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
- Levi-Montalcini R., Angeletti P. U. Nerve growth factor. Physiol Rev. 1968 Jul;48(3):534–569. doi: 10.1152/physrev.1968.48.3.534. [DOI] [PubMed] [Google Scholar]
- Takeda T., DeBusk J., Grollman A. Physiologic role of reninlike constituent of submaxillary gland of the mouse. Am J Physiol. 1969 May;216(5):1194–1198. doi: 10.1152/ajplegacy.1969.216.5.1194. [DOI] [PubMed] [Google Scholar]
- Takeda T., Grollman A. Inhibitory action of submaxillary gland on thymus and lymphoid tissues of the mouse. Am J Physiol. 1968 Dec;215(6):1337–1342. doi: 10.1152/ajplegacy.1968.215.6.1337. [DOI] [PubMed] [Google Scholar]
- Takeda T., Yamasaki Y., Yamabe H., Suzuki Y., Haebara H., Irino T., Grollman A. Atrophy of the lymphoid tissues of mice induced by extracts of the submaxillary gland. Proc Soc Exp Biol Med. 1967 Oct;126(1):212–216. doi: 10.3181/00379727-126-32404. [DOI] [PubMed] [Google Scholar]
