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. 1978 May;34(5):801–805.

Levels of total haemolytic complement activity in paired dairy cow-newborn calf sera.

H W Renshaw, W P Eckblad, P D Tassinari, D O Everson
PMCID: PMC1457201  PMID: 658979

Abstract

Total haemolytic complement (CH50) activities of sera obtained from newborn dairy calves and their corresponding dams were compared. The differences between the mean maternal and neonatal CH50 concentrations were significant (P less than or equal 0.001). The concentration of CH50 units/ml in sera from 16 calves was 52.0 +/- 21.4, whereas, for the cows it was 195.8 +/- 24.0. The ratio of cow: calf serum CH50 values averaged 4.24 with a range from 1.77 to 8.00. A positive rank correlation of 0.479 (P less than 0.05) was found between the CH50 titres in calves and their dams. Anticomplementary substances were not detected in calf sera. The possible relationships betweeen deficient CH50 levels in newborn calves and their susceptibility to infectious agents is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adinolfi M. Levels of wo components of complement (C'4 and C'3) in human fetal and newborn sera. Dev Med Child Neurol. 1970 Jun;12(3):306–308. [PubMed] [Google Scholar]
  2. Alper C. A., Abramson N., Johnston R. B., Jr, Jandl J. H., Rosen F. S. Studies in vivo and in vitro on an abnormality in the metabolism of C3 in a patient with increased susceptibility to infection. J Clin Invest. 1970 Nov;49(11):1975–1985. doi: 10.1172/JCI106417. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Barta O., Barta V. Haemolytic assay of bovine serum complement. J Immunol Methods. 1972 Aug;1(4):363–374. doi: 10.1016/0022-1759(72)90029-4. [DOI] [PubMed] [Google Scholar]
  4. Colten H. R. Biosynthesis of complement. Adv Immunol. 1976;22:67–118. doi: 10.1016/s0065-2776(08)60548-9. [DOI] [PubMed] [Google Scholar]
  5. FISHEL C. W., PEARLMAN D. S. Complement components of paired mother-cord sera. Proc Soc Exp Biol Med. 1961 Jul;107:695–699. doi: 10.3181/00379727-107-26731. [DOI] [PubMed] [Google Scholar]
  6. Fireman P., Zuchowski D. A., Taylor P. M. Development of human complement system. J Immunol. 1969 Jul;103(1):25–31. [PubMed] [Google Scholar]
  7. Kakoma I., Kinyanjui M. Complement levels of normal cattle. Res Vet Sci. 1974 May;16(3):395–397. [PubMed] [Google Scholar]
  8. RICE C. E., BOULANGER P. The interchangeability of the complement components of different animal species. IV. In the hemolysis of rabbit erythrocytes sensitized with sheep antibody. J Immunol. 1952 Feb;68(2):197–205. [PubMed] [Google Scholar]
  9. Renshaw H. W., Eckblad W. P., Thacker D. L., Frank F. W. Antibacterial host defense: in vitro interaction of bacteria, serum factors, and leukocytes from precolostral dairy calves and their dams. Am J Vet Res. 1976 Nov;37(11):1267–1274. [PubMed] [Google Scholar]
  10. Ruddy S., Gigli I., Austen K. F. The complement system of man. 3. N Engl J Med. 1972 Sep 21;287(12):592–596. doi: 10.1056/NEJM197209212871206. [DOI] [PubMed] [Google Scholar]

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