Skip to main content
PMC home page
Immunology logoLink to Immunology
. 1978 Jan;34(1):77–86.

Antibody mediated mechanisms of immunity to malaria induced by vaccination with Plasmodium knowlesi merozoites.

G A Butcher, G H Mitchell, S Cohen
PMCID: PMC1457343  PMID: 414993

Abstract

Rhesus monkeys vaccinated with merozoites in FCA are protected against challenge with several strains and variants of Plasmodium knowlesi. Vaccination induces sterilizing immunity which is species specific. Merozoite-blocking (inhibitory) antibody usually correlates with clinical immunity and protection can be passively transferred with immune sera provided these contain high levels of inhibitory antibody. However, vaccination using adjuvants other than FCA may induce inhibitory antibody without clinical protection. In addition, vaccinated animals may become susceptible to challenge 4-5 weeks after splenectomy, although inhibitory antibody levels are not reduced. These observations indicate that immunity induced by merozoite vaccination involves: (i) merozoite blocking (inhibitory) antibody, (ii) specific antibody or immune complexes acting synergistically with cytotoxic splenic cells stimulated by FCA.

Full text

PDF
77

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bannister L. H., Butcher G. A., Dennis E. D., Mitchell G. H. Structure and invasive behaviour of Plasmodium knowlesi merozoites in vitro. Parasitology. 1975 Dec;71(3):483–491. doi: 10.1017/s0031182000047247. [DOI] [PubMed] [Google Scholar]
  2. Brown I. N., Brown K. N., Hills L. A. Immunity to malaria: the antibody response to antigenic variation by Plasmodium knowlesi. Immunology. 1968 Jan;14(1):127–138. [PMC free article] [PubMed] [Google Scholar]
  3. Brown I. N. Immunological aspects of malaria infection. Adv Immunol. 1969;11:267–349. doi: 10.1016/s0065-2776(08)60481-2. [DOI] [PubMed] [Google Scholar]
  4. Brown I. N., Phillips R. S. Immunity to Plasmodium berghei in rats: passive serum transfer and role of the spleen. Infect Immun. 1974 Dec;10(6):1213–1218. doi: 10.1128/iai.10.6.1213-1218.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Brown K. N., Brown I. N., Hills L. A. Immunity to malaria. I. Protection against Plasmodium knowlesi shown by monkeys sensitized with drug-suppressed infections or by dead parasites in Freund's adjuvant. Exp Parasitol. 1970 Oct;28(2):304–317. doi: 10.1016/0014-4894(70)90101-3. [DOI] [PubMed] [Google Scholar]
  6. Brown K. N., Brown I. N. Immunity to malaria: antigenic variation in chronic infections of Plasmodium knowlesi. Nature. 1965 Dec 25;208(5017):1286–1288. doi: 10.1038/2081286a0. [DOI] [PubMed] [Google Scholar]
  7. Brown K. N., Hills L. A. Antigenic variation and immunity to Plasmodium knowlesi: antibodies which induce antigenic variation and antibodies which destroy parasites. Trans R Soc Trop Med Hyg. 1974;68(2):139–142. doi: 10.1016/0035-9203(74)90187-4. [DOI] [PubMed] [Google Scholar]
  8. Butcher G. A., Cohen S. Antigenic variation and protective immunity in Plasmodium knowlesi malaria. Immunology. 1972 Oct;23(4):503–521. [PMC free article] [PubMed] [Google Scholar]
  9. Clark I. A., Allison A. C., Cox F. E. Protection of mice against Babesia and Plasmodium with BCG. Nature. 1976 Jan 29;259(5541):309–311. doi: 10.1038/259309a0. [DOI] [PubMed] [Google Scholar]
  10. Cohen S., Butcher G. A., Crandall R. B. Action of malarial antibody in vitro. Nature. 1969 Jul 26;223(5204):368–371. doi: 10.1038/223368a0. [DOI] [PubMed] [Google Scholar]
  11. Cohen S. Mechanisms of malarial immunity. Trans R Soc Trop Med Hyg. 1977;71(4):283–286. doi: 10.1016/0035-9203(77)90100-6. [DOI] [PubMed] [Google Scholar]
  12. Dennis E. D., Mitchell G. H., Butcher G. A., Cohen S. In vitro isolation of Plasmodium knowlesi merozoites using polycarbonate sieves. Parasitology. 1975 Dec;71(3):475–481. doi: 10.1017/s0031182000047235. [DOI] [PubMed] [Google Scholar]
  13. Golenser J., Spira D. T., Zuckerman A. Neutralizing antibody in Rodent Malaria. Trans R Soc Trop Med Hyg. 1975;69(2):251–258. doi: 10.1016/0035-9203(75)90164-9. [DOI] [PubMed] [Google Scholar]
  14. Longenecker B. M., Breitenbach R. P., Congdon L. L., Farmer J. N. Natural and acquired antibodies to Plasmodium lophurae in intact and bursaless chickens. I. Agglutination and passive immunity studies. J Parasitol. 1969 Apr;55(2):418–425. [PubMed] [Google Scholar]
  15. McGregor I. A. Immunology of malarial infection and its possible consequences. Br Med Bull. 1972 Jan;28(1):22–27. doi: 10.1093/oxfordjournals.bmb.a070886. [DOI] [PubMed] [Google Scholar]
  16. Miller L. H., Aikawa M., Dvorak J. A. Malaria (Plasmodium knowlesi) merozoites: immunity and the surface coat. J Immunol. 1975 Apr;114(4):1237–1242. [PubMed] [Google Scholar]
  17. Mitchell G. H., Butcher G. A., Cohen S. Merozoite vaccination against Plasmodium knowlesi malaria. Immunology. 1975 Aug;29(2):397–407. [PMC free article] [PubMed] [Google Scholar]
  18. Mitchell G. H., Butcher G. A., Langhorne J., Cohen S. A freeze-dried merozoite vaccine effective against Plasmodium knowlesi malaria. Clin Exp Immunol. 1977 May;28(2):276–279. [PMC free article] [PubMed] [Google Scholar]
  19. Phillips R. S. Plasmodium berghei: passive transfer of immunity by antisera and cells. Exp Parasitol. 1970 Jun;27(3):479–495. doi: 10.1016/0014-4894(70)90052-4. [DOI] [PubMed] [Google Scholar]
  20. Rank R. G., Weidanz W. P., Bondi A. Nonsterilizing immunity in avian malaria: an antibody-independent phenomenon. Proc Soc Exp Biol Med. 1976 Feb;151(2):257–259. doi: 10.3181/00379727-151-39186. [DOI] [PubMed] [Google Scholar]
  21. Smalley M. E., Butcher G. A. The in vitro culture of the blood stages of Plasmodium berghei. Int J Parasitol. 1975 Apr;5(2):131–132. doi: 10.1016/0020-7519(75)90018-1. [DOI] [PubMed] [Google Scholar]
  22. Weinbaum F. I., Evans C. B., Tigelaar R. E. Immunity to Plasmodium Berghei yoelii in mice. I. The course of infection in T cell and B cell deficient mice. J Immunol. 1976 Nov;117(5 PT2):1999–2005. [PubMed] [Google Scholar]
  23. Wilson R. J., Phillips R. S. Method to test inhibitory antibodies in human sera to wild populations of Plasmodium falciparum. Nature. 1976 Sep 9;263(5573):132–134. doi: 10.1038/263132a0. [DOI] [PubMed] [Google Scholar]

Articles from Immunology are provided here courtesy of British Society for Immunology

RESOURCES