Skip to main content
NCBI home page
Immunology logoLink to Immunology
. 1979 Feb;36(2):215–220.

Neonatal thymus grafts. II. Cellular events.

M Dardenne, N Tubiana
PMCID: PMC1457486  PMID: 437831

Abstract

Neonatal thymus undergoes sequential necrosis and cell regeneration after grafting under the kidney capsule in normal and thymectomized recipients. This regeneration assessed in terms of cell number, response to mitogens, in vivo steroid sensitivity, level of antigen-binding cells, and cellular distribution on Ficoll gradient is not influenced by the presence of host thymus or by FTS injections. The grafted thymus shows a similar pattern of development as control thymus of the same age followed up in situ, with the exception of age-related involution the onset of which takes place earlier in the grafted thymus.

Full text

PDF
215

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bach J. F., Dardenne M. Antigen recognition by T lymphocytes. Thymus and marrow dependence of spontaneous rosette forming cells in the mouse. Cell Immunol. 1972 Jan;3(1):1–10. doi: 10.1016/0008-8749(72)90220-1. [DOI] [PubMed] [Google Scholar]
  2. Bach J. F., Dardenne M., Goldstein A. L., Guha A., White A. Appearance of T-cell markers in bone marrow rosette-forming cells after incubation with thymosin, a thymic hormone. Proc Natl Acad Sci U S A. 1971 Nov;68(11):2734–2738. doi: 10.1073/pnas.68.11.2734. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bach J. F., Dardenne M., Pleau J. M., Bach M. A. Isolation, biochemical characteristics, and biological activity of a circulating thymic hormone in the mouse and in the human. Ann N Y Acad Sci. 1975 Feb 28;249:186–210. doi: 10.1111/j.1749-6632.1975.tb29068.x. [DOI] [PubMed] [Google Scholar]
  4. Changes in laboratory investigation. Lab Invest. 1967 Jan;16(1):1–2. [PubMed] [Google Scholar]
  5. Cheers C., Leuchars E., Davies A. J., Wallis V. Restoration of thymectomized irradiated mice by frozen and stored thymus grafts. Transplantation. 1970 Dec;10(6):505–511. doi: 10.1097/00007890-197012000-00007. [DOI] [PubMed] [Google Scholar]
  6. Dardenne M., Charreire J., Bach J. F. Alterations in thymocyte surface markers after in vivo treatment by serum thymic factor. Cell Immunol. 1978 Aug;39(1):47–54. doi: 10.1016/0008-8749(78)90081-3. [DOI] [PubMed] [Google Scholar]
  7. Dukor P., Miller J. F., House W., Allman V. Regeneration of thymus grafts. I. Histological and cytological aspects. Transplantation. 1965 Sep;3(5):639–668. doi: 10.1097/00007890-196509000-00006. [DOI] [PubMed] [Google Scholar]
  8. Leuchars E., Morgan A., Davies A. J., Wallis V. J. Thymus grafts in thymectomized and normal mice. Nature. 1967 May 20;214(5090):801–802. doi: 10.1038/214801a0. [DOI] [PubMed] [Google Scholar]
  9. METCALF D. THE AUTONOMOUS BEHAVIOUR OF NORMAL THYMUS GRAFTS. Aust J Exp Biol Med Sci. 1963 Aug;41:SUPPL437–SUPPL447. doi: 10.1038/icb.1963.64. [DOI] [PubMed] [Google Scholar]
  10. METCALF D., WAKONIG-VAARTAJA R. STEM CELL REPLACEMENT IN NORMAL THYMUS GRAFTS. Proc Soc Exp Biol Med. 1964 Mar;115:731–735. doi: 10.3181/00379727-115-29022. [DOI] [PubMed] [Google Scholar]
  11. Mellstedt H. In vitro activation of human T and B lymphocytes by pokeweed mitogen. Clin Exp Immunol. 1975 Jan;19(1):75–82. [PMC free article] [PubMed] [Google Scholar]
  12. Yu D. T., Peter B. J., Paulus H. E., Machleder H. I. Lymphocyte populations: separation by discontinuous density gradient centrifugation. J Immunol. 1973 Jun;110(6):1615–1622. [PubMed] [Google Scholar]

Articles from Immunology are provided here courtesy of British Society for Immunology

RESOURCES