Skip to main content
Immunology logoLink to Immunology
. 1978 Nov;35(5):771–778.

Studies on the host-parasite relationship in Schistosoma mansoni-infected mice: the immunological dependence of parasite egg excretion.

M Doenhoff, R Musallam, J Bain, A McGregor
PMCID: PMC1457532  PMID: 309856

Abstract

CBA mice deprived of their T cells by means of thymectomy and anti-thymocyte serum and subsequently infected with Schistosoma mansoni were found to have substantially fewer parasite eggs in their faeces than similarly infected immunologically-intact control animals. The number of parasite eggs deposited in the tissues of T-cell deprived mice was by comparison only marginally lower than in control mice. Administration of serum obtained from normal mice with chronic S. mansoni infections partially restored the egg excretion rate in infected deprived mice, and also resulted in an increased number of eggs being deposited in the liver and intestine of these animals.

Full text

PDF
771

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Buchanan R. D., Fine D. P., Colley D. G. Schistosoma mansoni infection in mice depleted of thymus-dependent lymphocytes. II. Pathology and altered pathogenesis. Am J Pathol. 1973 May;71(2):207–218. [PMC free article] [PubMed] [Google Scholar]
  2. COKER C. M. Effect of cortisone on natural immunity to Schistosoma mansoni in mice. Proc Soc Exp Biol Med. 1957 Oct;96(1):1–3. doi: 10.3181/00379727-96-23377. [DOI] [PubMed] [Google Scholar]
  3. Cheever A. W. Conditions affecting the accuracy of potassium hydroxide digestion techniques for counting Schistosoma mansoni eggs in tissues. Bull World Health Organ. 1968;39(2):328–331. [PMC free article] [PubMed] [Google Scholar]
  4. Cunningham A. J., Szenberg A. Further improvements in the plaque technique for detecting single antibody-forming cells. Immunology. 1968 Apr;14(4):599–600. [PMC free article] [PubMed] [Google Scholar]
  5. Doenhoff M. J., Janossy G., Kerbel R. S. Enumeration of polyclonal mitogen-responsive cells in different lymphoid tissues of the mouse. Immunology. 1976 Mar;30(3):367–378. [PMC free article] [PubMed] [Google Scholar]
  6. Fine D. P., Buchanan R. D., Colley D. G. Schistosoma mansoni infection in mice depleted of thymus-dependent lymphocytes. I. Eosinophilia and immunologic responses to a schistosomal egg preparation. Am J Pathol. 1973 May;71(2):193–206. [PMC free article] [PubMed] [Google Scholar]
  7. Hsu C. K., Hsu S. H., Whitney R. A., Jr, Hansen C. T. Immunopathology of schistosomiasis in athymic mice. Nature. 1976 Jul 29;262(5567):397–399. doi: 10.1038/262397a0. [DOI] [PubMed] [Google Scholar]
  8. Kloetzel K. A collagenaselike substance produced by eggs of Schistosoma mansoni. J Parasitol. 1968 Feb;54(1):177–178. [PubMed] [Google Scholar]
  9. LAW L. W., BRADLEY T. R., ROSE S. REVERSAL OF THE THYMUS-DEPENDENT INFLUENCE IN RADIATION LEUKEMOGENESIS OF C57BL MICE. J Natl Cancer Inst. 1963 Dec;31:1461–1477. [PubMed] [Google Scholar]
  10. NEWSOME J. OBSERVATIONS ON CORTICOSTEROID TREATMENT OF SCHISTOSOMIASIS IN HAMSTERS AND BABOONS. Trans R Soc Trop Med Hyg. 1963 Nov;57:425–432. doi: 10.1016/0035-9203(63)90075-0. [DOI] [PubMed] [Google Scholar]
  11. Olivier L. J. Infectivity of Schistosoma mansoni cercariae. Am J Trop Med Hyg. 1966 Nov;15(6):882–885. doi: 10.4269/ajtmh.1966.15.882. [DOI] [PubMed] [Google Scholar]
  12. Pelley R. P., Pelley R. J., Hamburger J., Peters P. A., Warren K. S. Schistosoma mansoni soluble egg antigens. I. Identification and purification of three major antigens, and the employment of radioimmunoassay for their further characterization. J Immunol. 1976 Nov;117(5 Pt 1):1553–1560. [PubMed] [Google Scholar]
  13. Phillips S. M., DiConza J. J., Gold J. A., Reid W. A. Schistosomiasis in the congenitally athymic (nude) mouse. I. Thymic dependency of eosinophilia, granuloma formation, and host morbidity. J Immunol. 1977 Feb;118(2):594–599. [PubMed] [Google Scholar]
  14. Sheagren J. N., Monaco A. P. Protective Effect of Antilymphocyte Serum on Mice Infected with Plasmodium berghei. Science. 1969 Jun 20;164(3886):1423–1425. doi: 10.1126/science.164.3886.1423. [DOI] [PubMed] [Google Scholar]
  15. Smithers S. R., Terry R. J. The infection of laboratory hosts with cercariae of Schistosoma mansoni and the recovery of the adult worms. Parasitology. 1965 Nov;55(4):695–700. doi: 10.1017/s0031182000086248. [DOI] [PubMed] [Google Scholar]
  16. WEINMANN C. J., HUNTER G. W., 3rd Studies on schistosomiasis. 14. Effects of cortisone upon the Schistosoma mansoni burden in mice. Exp Parasitol. 1960 Jun;9:239–242. doi: 10.1016/0014-4894(60)90030-8. [DOI] [PubMed] [Google Scholar]
  17. WEINMANN C. J., HUNTER G. W., 3rd Studies on schistosomiasis. XVI. The effect of immune serum upon egg production by Schistosoma mansoni in mice. Exp Parasitol. 1961 Feb;11:56–62. doi: 10.1016/0014-4894(61)90007-8. [DOI] [PubMed] [Google Scholar]
  18. Warren K. S. Schistosomiasis: a multiplicity of immunopathology. J Invest Dermatol. 1976 Sep;67(3):464–469. doi: 10.1111/1523-1747.ep12514738. [DOI] [PubMed] [Google Scholar]
  19. Wright D. H., Masembe R. M., Bazira E. R. The effect of antithymocyte serum on golden hamsters and rats infected with Plasmodium berghei. Br J Exp Pathol. 1971 Oct;52(5):465–477. [PMC free article] [PubMed] [Google Scholar]
  20. Wright D. H. The effect of neonatal thymectomy on the survival of golden hamsters infected with Plasmodium berghei. Br J Exp Pathol. 1968 Aug;49(4):379–384. [PMC free article] [PubMed] [Google Scholar]

Articles from Immunology are provided here courtesy of British Society for Immunology

RESOURCES