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. 1978 Nov;35(5):849–855.

The mode of interaction with macrophages of two ordered synthetic polypeptides which differ in their thymus dependency.

M Schwartz, B Geiger, R Hooghe, M Bar-Eli, R Gallily, E Mozes, M Sela
PMCID: PMC1457533  PMID: 721143

Abstract

The mode of interaction with macrophages of two ordered synthetic polypeptides (Tyr-Tyr-Glu-Glu)-poly(DLAla)--poly(Lys), (T-T-G-G)-A--L, and (Tyr-Glu-Tyr-Glu)-poly(DLAla)--poly(Lys), (T-G-T-G)-A--L, which differ in their requirements for T-B cell co-operation in the process of antibody production, was compared. The binding of the two radiolabelled antigens to the surface of peritoneal adherent cells, their uptake by the cells and the rate of their degradation were investigated. Macrophages were found to be capable of degrading both poly-peptides with the same efficiency. (T-G-T-G)-A--L, the antigen which is less T-dependent, was bound to macrophage surfaces more readily than (T-T-G-G)-A--L, the T-dependent antigen, however, its uptake by the cells was found to be lower. Thus, (T-G-T-G)-A--L remains for a longer period in the form of a membrane bound polyvalent antigen.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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