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. 1978 Nov;35(5):811–816.

Experimental bovine trypanosomiasis. Changes in the catabolism of serum immunoglobulins and complement components in infected cattle.

K Nielsen, J Sheppard, W Holmes, I Tizard
PMCID: PMC1457546  PMID: 721141

Abstract

The turnover of serum proteins of calves experimentally infected with Trypanosoma congolense was compared to that of normal uninfected cattle. All proteins examined had much increased catabolic rates in infected animals. In normal animals the average half-lives in days for each protein were: IgG1 17.4, IgG2 22.4, IgM 4.8, IgA 3.4, IgE 1.9, C1 5.6 and C3 2.9. In trypanosome infected cattle the average half-lives were IgG1 1.9, IgG2 1.7, IgM 0.9, IgA 1.2, IgE 0.9, C1 1.2 and C3 1.1 days.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Chapman W. E., Ward P. A. Changes in C3 metabolism during protozoan infection (Babesia rodhaini) in rats. J Immunol. 1976 May;116(5):1284–1288. [PubMed] [Google Scholar]
  2. Chapman W. E., Ward P. A. The complement profile in babesiosis. J Immunol. 1976 Sep;117(3):935–938. [PubMed] [Google Scholar]
  3. Clarkson M. J., Penhale W. J., Edwards G., Farrell P. J. Serum protein changes in cattle infected with Trypanosoma vivax. Trans R Soc Trop Med Hyg. 1975;69(1):2–3. [PubMed] [Google Scholar]
  4. Freeman T., Smithers S. R., Targett G. A., Walk P. J. Specificity of immunoglobulin G in rhesus monkeys infected with Schistosoma mansoni, Plasmodium knowlesi, and Trypanosoma brucei. J Infect Dis. 1970 Apr;121(4):401–406. doi: 10.1093/infdis/121.4.401. [DOI] [PubMed] [Google Scholar]
  5. Hudson K. M., Byner C., Freeman J., Terry R. J. Immunodepression, high IgM levels and evasion of the immune response in murine trypanosomiasis. Nature. 1976 Nov 18;264(5583):256–258. doi: 10.1038/264256a0. [DOI] [PubMed] [Google Scholar]
  6. Jennings F. W., Murray P. K., Murray M., Urquhart G. M. Protein catabolism in trypanosomiasis. Trans R Soc Trop Med Hyg. 1973;67(2):277–277. doi: 10.1016/0035-9203(73)90191-0. [DOI] [PubMed] [Google Scholar]
  7. Kobayashi A., Tizard I. R. The response to Trypanosoma congolense infection in calves. Determination of immunoglobulins igG1, igG2, igM and C3 levels and the complement fixing antibody titres during the course of infection. Tropenmed Parasitol. 1976 Dec;27(4):411–417. [PubMed] [Google Scholar]
  8. Luckins A. G., Mehlitz D. Observations on serum immunoglobulin levels in cattle infected with Trypanosoma brucei, T. vivax and T. congolense. Ann Trop Med Parasitol. 1976 Dec;70(4):479–480. doi: 10.1080/00034983.1976.11687153. [DOI] [PubMed] [Google Scholar]
  9. McConahey P. J., Dixon F. J. A method of trace iodination of proteins for immunologic studies. Int Arch Allergy Appl Immunol. 1966;29(2):185–189. doi: 10.1159/000229699. [DOI] [PubMed] [Google Scholar]
  10. Moulton J. E., Coleman J. L. Immunosuppression in deer mice with experimentally induced trypanosomiasis. Am J Vet Res. 1977 May;38(5):573–579. [PubMed] [Google Scholar]
  11. Nagle R. B., Ward P. A., Lindsley H. B., Sadun E. H., Johnson A. J., Berkaw R. E., Hildebrandt P. K. Experimental infections with African Trypanosomes. VI. Glomerulonephritis involving the alternate pathway of complement activation. Am J Trop Med Hyg. 1974 Jan;23(1):15–26. [PubMed] [Google Scholar]
  12. Nielsen K., Sheppard J. Activation of complement by trypanosomes. Experientia. 1977 Jun 15;33(6):769–771. doi: 10.1007/BF01944182. [DOI] [PubMed] [Google Scholar]
  13. Nielsen K., Sheppard J., Holmes W., Tizard I. Experimental bovine trypanosomiasis. Changes in serum immunoglobulins, complement and complement components in infected animals. Immunology. 1978 Nov;35(5):817–826. [PMC free article] [PubMed] [Google Scholar]
  14. Papamichail M., Gutierrez C., Embling P., Johnson P., Holborow E. J., Pepys M. B. Complement dependence of localisation of aggregated IgG in germinal centres. Scand J Immunol. 1975;4(4):343–347. doi: 10.1111/j.1365-3083.1975.tb02635.x. [DOI] [PubMed] [Google Scholar]
  15. Pepys M. B. Role of complement in the induction of immunological responses. Transplant Rev. 1976;32:93–120. doi: 10.1111/j.1600-065x.1976.tb00230.x. [DOI] [PubMed] [Google Scholar]
  16. Terry R. J., Freeman J., Hudson K. M., Longstaffe J. A. Immunoglobulin M production and immunosuppression in trypanosomiasis: a linking hypothesis. Trans R Soc Trop Med Hyg. 1973;67(2):263–263. doi: 10.1016/0035-9203(73)90167-3. [DOI] [PubMed] [Google Scholar]

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