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. 1979 Mar;36(3):519–525.

Failure to block lymphocyte Fc receptor with anti-B lymphocyte sera (anti-DRW) in man.

J P Soulillou, M A Peyrat
PMCID: PMC1457570  PMID: 312261

Abstract

Sera harvested from multiparous women or from allograft recipients who had rejected their kidneys and containing various anti-DRW specificities, were studied on peripheral blood or lymph-node lymphocytes bearing or lacking the relevant B-cell alloantigen, for their EA or EAC-rosette-inhibition activity. Inhibition of C3 or Fc-receptor occurred independently of their anti-B lymphocyte cytotoxicity pattern. The same conclusion was reached when lymphocytes were either macrophage depleted or B-lymphocyte enriched. These results do not suggest a relationship in man between B-lymphocyte (DRW) alloantigen and Fc or C3 receptor structure.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Arbeit R. D., Sachs D. H., Amos D. B., Dickler H. B. Human lymphocyte alloantigen(s) similar to murine Ir region-associated (Ia) antigens. J Immunol. 1975 Oct;115(4):1173–1175. [PubMed] [Google Scholar]
  2. Arnaiz-Villena A., Festenstein H. 4a(W4) and 4b(W6) human histocompatibility antigens are specifically associated with complement receptors. Nature. 1975 Dec 25;258(5537):732–734. doi: 10.1038/258732a0. [DOI] [PubMed] [Google Scholar]
  3. Basten A., Miller J. F., Abraham R. Relationship between Fc receptors, antigen-binding sites on T and B cells, and H-2 complex-associated determinants. J Exp Med. 1975 Mar 1;141(3):547–560. doi: 10.1084/jem.141.3.547. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Dickler H. B., Kubicek M. T., Arbeit R. D., Sharrow S. O. Studies on the nature of the relationship between Ia antigens and Fc receptors on murine B lymphocytes. J Immunol. 1977 Jul;119(1):348–354. [PubMed] [Google Scholar]
  5. Dickler H. B., Sachs D. H. Evidence for identity or close association of the Fc receptor of B lymphocytes and alloantigens determined by the Ir region of the H-2 complex. J Exp Med. 1974 Sep 1;140(3):779–796. doi: 10.1084/jem.140.3.779. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Ezer G., Hayward A. R. Inhibition of complement-dependent lymphocyte rosette formation: a possible test for activated complement products. Eur J Immunol. 1974 Feb;4(2):148–150. doi: 10.1002/eji.1830040216. [DOI] [PubMed] [Google Scholar]
  7. JACKSON J. F. Supravital blood studies, using acridine orange fluorescence. Blood. 1961 May;17:643–649. [PubMed] [Google Scholar]
  8. Kerbel R. S., Davies A. J. The possible biological significance of Fc receptors on mammalian lymphocytes and tumor cells. Cell. 1974 Oct;3(2):105–112. doi: 10.1016/0092-8674(74)90113-5. [DOI] [PubMed] [Google Scholar]
  9. Nussenzweig V. Receptors for immune complexes on lymphocytes. Adv Immunol. 1974;19(0):217–258. doi: 10.1016/s0065-2776(08)60253-9. [DOI] [PubMed] [Google Scholar]
  10. Rask L., Klarkeskog L., Ostberg L., Peterson P. A. Isolation and properties of a murine spleen cell Fc receptor. Nature. 1975 Sep 18;257(5523):231–233. doi: 10.1038/257231a0. [DOI] [PubMed] [Google Scholar]
  11. Ryan J. L., Arbeit R. D., Dickler H. B., Henkart P. A. Inhibition of lymphocyte mitogenesis by immobilized antigen-antibody complexes. J Exp Med. 1975 Oct 1;142(4):814–826. doi: 10.1084/jem.142.4.814. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Schirrmacher V., Halloran P., David C. S. Interactions of Fc receptors with antibodies against Ia antigens and other cell surface components. J Exp Med. 1975 May 1;141(5):1201–1209. doi: 10.1084/jem.141.5.1201. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Soulillou J. P., Carpenter C. B., d'Apice A. J., Strom T. B. The role of nonclassical Fc receptor-associated, Ag-B antigens (Ia) in rat allograft enhancement. J Exp Med. 1976 Feb 1;143(2):405–421. doi: 10.1084/jem.143.2.405. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Soulillou J. P., Peyrat M. A., Guenel J. Association between treatment-resistant kidney-allograft rejection and post-transplant appearance of antibodies to donor B-lymphocyte alloantigens. Lancet. 1978 Feb 18;1(8060):354–356. doi: 10.1016/s0140-6736(78)91081-4. [DOI] [PubMed] [Google Scholar]
  15. Spiegelberg H. L., Perlmann H., Perlmann P. Interaction of K lymphocytes with myeloma proteins of different IgG subclasses. J Immunol. 1976 Nov;117(5 Pt 1):1464–1471. [PubMed] [Google Scholar]
  16. Suthanthiran M., Gailiunas P., Fagan G., Strom T. B., Carpenter C. B., Garovoy M. R. Detection of anti-donor "Ia" antibodies: a strong correlate of rejection. Transplant Proc. 1978 Sep;10(3):605–607. [PubMed] [Google Scholar]
  17. Suthanthiran M., Garovoy M. R., Fagan G., Gailiunas P., Carpenter C. B. Evidence for close association between B-cell Fc receptors and Ia antigens, and independence from HLA-A,B locus-determined antigens. Transplant Proc. 1977 Dec;9(4):1705–1707. [PubMed] [Google Scholar]
  18. Territo M. C., Cline M. J. Monocyte function in man. J Immunol. 1977 Jan;118(1):187–192. [PubMed] [Google Scholar]
  19. Wofsy L., McDevitt H. O., Henry C. No direct association between Ia antigens and Fc receptors on the B cell membrane. J Immunol. 1977 Jul;119(1):61–64. [PubMed] [Google Scholar]

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