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. 1979 Mar;36(3):527–532.

Functional maturation of neonatal spleen cells.

R Bösing-Schneider
PMCID: PMC1457571  PMID: 312262

Abstract

Maturation of neonatal spleen cells was studied in vitro with a cell population restricted with respect to functional properties. It is shown that the onset of the immune response to SRBc in post-natal mice was delayed because B and T cells were incompetent. It appears, however, that the development of these two cell populations does not occur in parallel. Since the addition of adult macrophages failed to overcome the incompetence of neonatal B cells in the presence of a T cell replacing factor, it is suggested that the late appearance of immune competence is due to the inability of B cells to process a T-cell signal.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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