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. 1978 Mar;34(3):371–378.

A possible role for polymorphonuclear leucocytes in the defence against recrudescent herpes simplex virus infection in man.

A S Russell, C Miller
PMCID: PMC1457618  PMID: 640713

Abstract

We have used a 51Cr release assay to demonstrate that human polymorphonuclear leucocytes (PMNL) can damage herpes simplex infected target cells sensitized with antiviral antibody. Effective sensitizing antibodies were found in both serum and saliva of all those persons tested who were subject to recurrent cold sores. PMNL were much less effective as killer cells than peripheral blood mononuclear cells, but as they are the predominant inflammatory cell with the HSV1 lesion they may be, quantitatively, more important. The cytotoxic effects of both PMNL and mononuclear cells were significantly reduced by prostaglandin E1 as well as by several drugs that were tested. It is suggested that antibody dependent PMNL-mediated cytotoxicity may play a role in the human host defences against recrudescent herpes simplex infection.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Eden A., Miller G. W., Nussenzweig V. Human lymphocytes bear membrane receptors for C3b and C3d. J Clin Invest. 1973 Dec;52(12):3239–3242. doi: 10.1172/JCI107525. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Harris R., Ukaejiofo E. O. Rapid preparation of lymphocytes for tissue-typing. Lancet. 1969 Aug 9;2(7615):327–327. doi: 10.1016/s0140-6736(69)90096-8. [DOI] [PubMed] [Google Scholar]
  3. Hill T. J., Blyth W. A. An alternative theory of herpes-simplex recurrence and a possible role for prostaglandins. Lancet. 1976 Feb 21;1(7956):397–399. doi: 10.1016/s0140-6736(76)90220-8. [DOI] [PubMed] [Google Scholar]
  4. Hill T. J., Field H. J., Blyth W. A. Acute and recurrent infection with herpes simplex virus in the mouse: a model for studying latency and recurrent disease. J Gen Virol. 1975 Sep;28(3):341–353. doi: 10.1099/0022-1317-28-3-341. [DOI] [PubMed] [Google Scholar]
  5. Lodmell D. L., Niwa A., Hayashi K., Notkins A. L. Prevention of cell-to-cell spread of herpes simplex virus by leukocytes. J Exp Med. 1973 Mar 1;137(3):706–720. doi: 10.1084/jem.137.3.706. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Mantovani B. Different roles of IgG and complement receptors in phagocytosis by polymorphonuclear leukocytes. J Immunol. 1975 Jul;115(1):15–17. [PubMed] [Google Scholar]
  7. McSorley J., Shapiro L., Brownstein M. H., Hsu K. C. Herpes simplex and varicella-zoster: comparative histopathology of 77 cases. Int J Dermatol. 1974 Mar-Apr;13(2):69–75. doi: 10.1111/j.1365-4362.1974.tb01769.x. [DOI] [PubMed] [Google Scholar]
  8. Merigan T. C. Host defenses against viral disease. N Engl J Med. 1974 Feb 7;290(6):323–329. doi: 10.1056/NEJM197402072900608. [DOI] [PubMed] [Google Scholar]
  9. Perlmann P., Perlmann H. Contactual lysis of antibody-coated chicken erythrocytes by purified lymphocytes. Cell Immunol. 1970 Sep;1(3):300–315. doi: 10.1016/0008-8749(70)90051-1. [DOI] [PubMed] [Google Scholar]
  10. Pfizenmaier K., Starzinski-Powitz A., Röllinghoff M., Falks D., Wagner H. T-cell-mediated cytotoxicity against herpes simplex virus-infected target cells. Nature. 1977 Feb 17;265(5595):630–632. doi: 10.1038/265630a0. [DOI] [PubMed] [Google Scholar]
  11. Rasmussen L. E., Jordan G. W., Stevens D. A., Merigan T. C. Lymphocyte interferon production and transformation after Herpes simplex infections in humans. J Immunol. 1974 Feb;112(2):728–736. [PubMed] [Google Scholar]
  12. Russell A. S., Essery G. Cellular immunity to herpes simplex virus in man. VII. K-cell activity to HSV1 infected target cells in disease. Cancer. 1977 Jul;40(1):42–45. doi: 10.1002/1097-0142(197707)40:1<42::aid-cncr2820400109>3.0.co;2-f. [DOI] [PubMed] [Google Scholar]
  13. Russell A. S., Kaiser J. T. Cell-mediated immunity to herpes simplex virus in man. V. Antibody-mediated cell-dependent immune lysis of herpes virus-infected target cells. J Allergy Clin Immunol. 1976 Nov;58(5):539–545. doi: 10.1016/0091-6749(76)90199-8. [DOI] [PubMed] [Google Scholar]
  14. Russell A. S., Percy J. S., Kovithavongs T. Cell-mediated immunity to Herpes simplex in humans: lymphocyte cytotoxicity measured by 51-Cr release from infected cells. Infect Immun. 1975 Feb;11(2):355–359. doi: 10.1128/iai.11.2.355-359.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. STOKER M. G. Mode of intercellular transfer of herpes virus. Nature. 1958 Nov 29;182(4648):1525–1526. doi: 10.1038/1821525a0. [DOI] [PubMed] [Google Scholar]
  16. Severson C. D., Greazel N. A., Thompson J. S. Micro-capillary agglutination. J Immunol Methods. 1974 Mar;4(2):369–380. doi: 10.1016/0022-1759(74)90078-7. [DOI] [PubMed] [Google Scholar]
  17. Shore S. L., Cromeans T. L., Romano T. J. Immune destruction of virus-infected cells early in the infectious cycle. Nature. 1976 Aug 19;262(5570):695–696. doi: 10.1038/262695a0. [DOI] [PubMed] [Google Scholar]
  18. Shore S. L., Melewicz F. M., Gordon D. S. The mononuclear cell in human blood which mediates antibody-dependent cellular cytotoxicity to virus-infected target cells. I. Identification of the population of effector cells. J Immunol. 1977 Feb;118(2):558–566. [PubMed] [Google Scholar]
  19. Shore S. L., Nahmias A. J., Starr S. E., Wood P. A., McFarlin D. E. Detection of cell-dependent cytotoxic antibody to cells infected with herpes simplex virus. Nature. 1974 Sep 27;251(5473):350–352. doi: 10.1038/251350a0. [DOI] [PubMed] [Google Scholar]
  20. Wardley R. C., Babiuk L. A., Rouse B. T. Polymorph-mediated antibody-dependent cytoxicity--modulation of activity by drugs and immune interferon. Can J Microbiol. 1976 Sep;22(9):1222–1228. doi: 10.1139/m76-181. [DOI] [PubMed] [Google Scholar]
  21. Wilton J. M., Ivanyi L., Lehner T. Cell-mediated immunity in Herpesvirus hominis infections. Br Med J. 1972 Mar 18;1(5802):723–726. doi: 10.1136/bmj.1.5802.723. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Yust I., Smith R. W., Wunderlich J. R., Mann D. L. Temporary inhibition of antibody-dependent, cell-mediated cytotoxicity by pretreatment of human attacking cells with ammonium chloride. J Immunol. 1976 Apr;116(4):1170–1172. [PubMed] [Google Scholar]
  23. Zighelboim J., Gale R. P., Kedar E. Polymorphonuclear leukocyte Fc receptors in antibody-dependent cellular cytotoxicity (ADCC). Transplantation. 1976 Jun;21(6):524–526. doi: 10.1097/00007890-197606000-00016. [DOI] [PubMed] [Google Scholar]

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