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. 1996 Apr 1;24(7):1360–1368. doi: 10.1093/nar/24.7.1360

Positive elements in the laminin gamma 1 gene synergize to activate high level transcription during cellular differentiation.

H S Chang 1, N B Kim 1, S L Phillips 1
PMCID: PMC145770  PMID: 8614642

Abstract

Transcription of the murine laminin gamma 1 gene is activated during retinoic acid/cAMP induced differentiation of F9 embryonal carcinoma cells. Positive transcription control elements associated with two DNase I hypersensitive regions in the large first intron of the gene have been identified which confer a differentiation response on the laminin gamma 1 promoter. However, the kinetics of transcriptional activation suggest each DNA region interacts with transcription factors appearing at different times during differentiation. Synergy between the two regions in cis causes high level activation.

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Selected References

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