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. 1980 Jan;39(1):61–65.

Differences in calcium requirements for B-cell tolerance and immunity.

C Desaymard, R A Shinton, H Waldmann
PMCID: PMC1457775  PMID: 6991396

Abstract

Incubation of unprimed spleen B cells with high concentrations of hapten-conjugates resulted in the induction of specific unresponsiveness or tolerance to a subsequent encounter with the hapten on a potentially immunogenic carrier. This process of tolerance induction could occur in the absence of extracellular calcium. In contrast B-cell activation to both proliferation and subsequent antibody secretion is known to be calcium dependent. This means that either (1) the decisions which determine immunity and tolerance in B cells are mediated through totally distinct signalling pathways, or that (2) if tolerance and immunity depend on same common signalling events, then the commitment of B cells to switch on or off must be determined at a very early stage.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alford R. H. Metal cation requirements for phytohemagglutinin-induced transformation of human peripheral blood lymphocytes. J Immunol. 1970 Mar;104(3):698–703. [PubMed] [Google Scholar]
  2. Cunningham A. J., Szenberg A. Further improvements in the plaque technique for detecting single antibody-forming cells. Immunology. 1968 Apr;14(4):599–600. [PMC free article] [PubMed] [Google Scholar]
  3. Desaymard C., Feldmann M. Lack of requirement for cell cooperation in the antibody response to DNP conjugated to levan. Cell Immunol. 1975 Mar;16(1):106–114. doi: 10.1016/0008-8749(75)90189-6. [DOI] [PubMed] [Google Scholar]
  4. Diamantstein T., Odenwald M. V. Control of the immune response in vitro by calcium ions. I. The antagonistic action of calcium ions on cell proliferation and on cell differentiation. Immunology. 1974 Oct;27(4):531–541. [PMC free article] [PubMed] [Google Scholar]
  5. Diamantstein T., Ulmer A. The antagonistic action of cyclic GMP and cyclic AMP on proliferation of B and T lymphocytes. Immunology. 1975 Jan;28(1):113–119. [PMC free article] [PubMed] [Google Scholar]
  6. Diamantstein T., Ulmer A. The control of immune response in vitro by Ca2+. II. The Ca2+-dependent period during mitogenic stimulation. Immunology. 1975 Jan;28(1):121–125. [PMC free article] [PubMed] [Google Scholar]
  7. Diener E., Feldmann M. Relationship between antigen and antibody-induced suppression of immunity. Transplant Rev. 1972;8:76–103. doi: 10.1111/j.1600-065x.1972.tb01565.x. [DOI] [PubMed] [Google Scholar]
  8. Kvarstein B. Oxygen consumption during the initial stage of human leucocyte phagocytosis of polystyrene latex particles. Scand J Clin Lab Invest. 1970 Jun;25(4):337–348. doi: 10.3109/00365517009046214. [DOI] [PubMed] [Google Scholar]
  9. Möller G., Fernandez C. Immunological tolerance to the thymus-independent antigen dextran can be abrogated by thymus-dependent dextran conjugates: evidence against clonal deletion as the mechanism of tolerance induction. Scand J Immunol. 1978;8(1):29–37. doi: 10.1111/j.1365-3083.1978.tb00493.x. [DOI] [PubMed] [Google Scholar]
  10. Rittenberg M. B., Amkraut A. A. Immunogenicity of trinitrophenyl-hemocyanin: production of primary and secondary anti-hapten precipitins. J Immunol. 1966 Sep;97(3):421–430. [PubMed] [Google Scholar]
  11. Schrader J. W., Nossal G. J. Effector cell blockade. A new mechanism of immune hyporeactivity induced by multivalent antigens. J Exp Med. 1974 Jun 1;139(6):1582–1598. doi: 10.1084/jem.139.6.1582. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Schreiner G. F., Unanue E. R. Calcium-sensitive modulation of Ig capping: evidence supporting a cytoplasmic control of ligand-receptor complexes. J Exp Med. 1976 Jan 1;143(1):15–31. doi: 10.1084/jem.143.1.15. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Slowe A., Waldmann H. The 'intrinsic adjuvanticity' and immunogenicity of trinitrophenylated lipopolysaccharide. Immunology. 1975 Nov;29(5):825–834. [PMC free article] [PubMed] [Google Scholar]
  14. Waldmann H., Munro A. The inter-relationship of antigenic structure, thymus-independence and adjuvanticity. IV. A general model for B-cell induction. Immunology. 1975 Mar;28(3):509–522. [PMC free article] [PubMed] [Google Scholar]
  15. Waldmann H., Pope H. Can B-cell tolerance be induced by oligovalent thymus dependent antigens? Immunology. 1977 May;32(5):657–667. [PMC free article] [PubMed] [Google Scholar]
  16. Whitney R. B., Sutherland R. M. Requirement for calcium ions in lymphocyte transformation stimulated by phytohemagglutinin. J Cell Physiol. 1972 Dec;80(3):329–337. doi: 10.1002/jcp.1040800303. [DOI] [PubMed] [Google Scholar]

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