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. 1980 Jan;39(1):11–20.

The induction of suppressor cells in mixed leucocyte cultures and in mixed leucocyte-non-lymphoid cell cultures.

G Pawelec
PMCID: PMC1457781  PMID: 6445866

Abstract

X-ray resistant porcine suppressor T cells expressing Ia-like antigens were obtained from mixed cultures of leucocytes and tissue cells (cultured kidney cells, liver cells, endothelial cells, fibroblasts or X-irradiated leucocytes), and were assayed by their ability to suppress lymphocyte proliferation in a second mixed culture. All tissues tested induced suppressor cells although quantitative differences existed between them. Suppressor cell induction was under genetic control by at least two loci, one of which was within the major histocompatibility (MHC) complex. Suppressor cell function was restricted by the MHC type of the responding cell but not the stimulating cell in the second culture.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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