Abstract
Immunofluorescence and cytolysis studies using antisera against the xeno- and alloantigenic components of the Thy-1 molecule have shown that in adult mouse bone marrow more cells bear the xeno than the alloantigen. Allo+ cells form a subset of a larger, xeno+ population. Xeno+ allo- 'prothymocytes' can be induced to express the alloantigen in vitro; this could result from the unmasking of cryptic antigen, the presence of which is demonstrated, rather than de novo antigen synthesis. Some xeno+ allo- cells are involved in splenic haemopoiesis, either as a subpopulation of precursors, or as accessory helper cells.
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- Acton R. T., Morris R. J., Williams A. F. Estimation of the amount and tissue distribution of rat Thy-1.1 antigen. Eur J Immunol. 1974 Sep;4(9):598–602. doi: 10.1002/eji.1830040904. [DOI] [PubMed] [Google Scholar]
- Bach M. A., Bach J. F. Studies on thymus products. VI. The effects of cyclic nucleotides and prostaglandins on rosette-forming cells. Interactions with thymic factor. Eur J Immunol. 1973 Dec;3(12):778–783. doi: 10.1002/eji.1830031208. [DOI] [PubMed] [Google Scholar]
- Barclay A. N., Letarte-Muirhead M., Williams A. F. Purification of the Thy-1 molecule from rat brain. Biochem J. 1975 Dec;151(3):699–706. doi: 10.1042/bj1510699. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Basch R. S., Goldstein G. Induction of T-cell differentiation in vitro by thymin, a purified polypeptide hormone of the thymus. Proc Natl Acad Sci U S A. 1974 Apr;71(4):1474–1478. doi: 10.1073/pnas.71.4.1474. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cohen A., Schlesinger M. Absorption of guinea pig serum with agar. A method for elimination of itscytotoxicity for murine thymus cells. Transplantation. 1970 Jul;10(1):130–132. doi: 10.1097/00007890-197007000-00027. [DOI] [PubMed] [Google Scholar]
- Devreotes P. N., Gardner J. M., Fambrough D. M. Kinetics of biosynthesis of acetylcholine receptor and subsequent incorporation into plasma membrane of cultured chick skeletal muscle. Cell. 1977 Mar;10(3):365–373. doi: 10.1016/0092-8674(77)90023-x. [DOI] [PubMed] [Google Scholar]
- Douglas T. C. A rat analog of the mouse theta antigen. Transplant Proc. 1973 Mar;5(1):79–82. [PubMed] [Google Scholar]
- Doyle D., Baumann H., England B., Friedman E., Hou E., Tweto J. Biogenesis of plasma membrane glycoproteins in hepatoma tissue culture cells. J Biol Chem. 1978 Feb 10;253(3):965–973. [PubMed] [Google Scholar]
- Goldschneider I., Gordon L. K., Morris R. J. Demonstration of Thy-1 antigen on pluripotent hemopoietic stem cells in the rat. J Exp Med. 1978 Nov 1;148(5):1351–1366. doi: 10.1084/jem.148.5.1351. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Golub E. S. Brain-associated stem cell antigen: an antigen shared by brain and hemopoietic stem cells. J Exp Med. 1972 Aug 1;136(2):369–374. doi: 10.1084/jem.136.2.369. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hunt S. V., Mason D. W., Williams A. F. In rat bone marrow Thy-1 antigen is present on cells with membrane immunoglobulin and on precursors of peripheral B lymphocytes. Eur J Immunol. 1977 Nov;7(11):817–823. doi: 10.1002/eji.1830071114. [DOI] [PubMed] [Google Scholar]
- Komuro K., Boyse E. A. In-vitro demonstration of thymic hormone in the mouse by conversion of precursor cells into lymphocytes. Lancet. 1973 Apr 7;1(7806):740–743. doi: 10.1016/s0140-6736(73)92127-2. [DOI] [PubMed] [Google Scholar]
- Lennon V. A., Unger M., Dulbecco R. Thy-1: a differentiation marker of potential mammary myoepithelial cells in vitro. Proc Natl Acad Sci U S A. 1978 Dec;75(12):6093–6097. doi: 10.1073/pnas.75.12.6093. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Milewicz C., Miller H. C., Esselman W. J. Membrane expression of Thy-1,2 and GM1 ganglioside on differentiating T lymphocytes. J Immunol. 1976 Nov;117(5 PT2):1774–1780. [PubMed] [Google Scholar]
- Morris R. J., Letarte-Muirhead M., Williams A. F. Analysis in deoxycholate of three antigenic specificities associated with the rat Thy-1 molecule. Eur J Immunol. 1975 Apr;5(4):282–285. doi: 10.1002/eji.1830050413. [DOI] [PubMed] [Google Scholar]
- Morris R. J., Williams A. F. Antigens on mouse and rat lymphocytes recognized by rabbit antiserum against rat brain: the quantitative analysis of a xenogeneic antiserum. Eur J Immunol. 1975 Apr;5(4):274–281. doi: 10.1002/eji.1830050412. [DOI] [PubMed] [Google Scholar]
- Morris R. J., Williams A. F. Serological and preliminary biochemical characteristics of a T lymphocyte differentiation antigen detected by rabbit antiserum to rat thymocyte membranes. Eur J Immunol. 1977 Jun;7(6):360–366. doi: 10.1002/eji.1830070607. [DOI] [PubMed] [Google Scholar]
- Muirhead M. L., Action R. T., Williams A. F. Preliminary characterization of Thy-1.1 and Ag-B antigens from rat tissues solubilized in detergents. Biochem J. 1974 Oct;143(1):51–61. doi: 10.1042/bj1430051. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Nelson P., Christian C., Nirenberg M. Synapse formation between clonal neuroblastoma X glioma hybrid cells and striated muscle cells. Proc Natl Acad Sci U S A. 1976 Jan;73(1):123–127. doi: 10.1073/pnas.73.1.123. [DOI] [PMC free article] [PubMed] [Google Scholar]
- REIF A. E., ALLEN J. M. THE AKR THYMIC ANTIGEN AND ITS DISTRIBUTION IN LEUKEMIAS AND NERVOUS TISSUES. J Exp Med. 1964 Sep 1;120:413–433. doi: 10.1084/jem.120.3.413. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Raff M. C. Two distinct populations of peripheral lymphocytes in mice distinguishable by immunofluorescence. Immunology. 1970 Oct;19(4):637–650. [PMC free article] [PubMed] [Google Scholar]
- Ritter M. A., Gordon L. K., Goldschneider I. Distribution of identity of Thy-1-bearing cells during ontogeny in rat hemopoietic and lymphoid tissues. J Immunol. 1978 Dec;121(6):2463–2471. [PubMed] [Google Scholar]
- Roelants G. E., Loor F., von Boehmer H., Sprent J., Hägg L. B., Mayor K. S., Rydén A. Five types of lymphocytes (Ig-theta-, Ig-theta+weak, Ig-theta+strong, Ig+theta- and Ig+theta+) characterized by double immunofluorescence and electrophoretic mobility. Organ distribution in normal and nude mice. Eur J Immunol. 1975 Feb;5(2):127–131. doi: 10.1002/eji.1830050211. [DOI] [PubMed] [Google Scholar]
- Roelants G. E., Mayor K. S., Hägg L. B., Loor F. Immature T lineage lymphocytes in athymic mice. Presence of TL, lifespan and homeostatic regulation. Eur J Immunol. 1976 Feb;6(2):75–81. doi: 10.1002/eji.1830060202. [DOI] [PubMed] [Google Scholar]
- Scheid M. P., Goldstein G., Boyse E. A. The generation and regulation of lymphocyte populations: evidence from differentiative induction systems in vitro. J Exp Med. 1978 Jun 1;147(6):1727–1743. doi: 10.1084/jem.147.6.1727. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Scheid M. P., Hoffmann M. K., Komuro K., Hämmerling U., Abbott J., Boyse E. A., Cohen G. H., Hooper J. A., Schulof R. S., Goldstein A. L. Differentiation of T cells induced by preparations from thymus and by nonthymic agents. J Exp Med. 1973 Oct 1;138(4):1027–1032. doi: 10.1084/jem.138.4.1027. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shortman K. The separation of different cell classes from lymphoid organs. II. The purification and analysis of lymphocyte populations by equilibrium density gradient centrifugation. Aust J Exp Biol Med Sci. 1968 Aug;46(4):375–396. doi: 10.1038/icb.1968.32. [DOI] [PubMed] [Google Scholar]
- Storrie B., Goldstein G., Boyse E. A., Hammerling U. Differentiation of thymocytes: evidence that induction of the surface phenotype requires transcription and translation. J Immunol. 1976 May;116(5):1358–1362. [PubMed] [Google Scholar]
- TILL J. E., McCULLOCH E. A. A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. Radiat Res. 1961 Feb;14:213–222. [PubMed] [Google Scholar]
- Thierfelder S. Haemopoietic stem cells of rats but not of mice express Th-1.1 alloantigen. Nature. 1977 Oct 20;269(5630):691–693. doi: 10.1038/269691a0. [DOI] [PubMed] [Google Scholar]
- Thomas D. B., Calderon R. A., Blaxland L. J. A new Thy-1 alloantigen as a temporal marker of T lymphocyte differentiation. Nature. 1978 Oct 26;275(5682):711–715. doi: 10.1038/275711a0. [DOI] [PubMed] [Google Scholar]
- Trowbridge I. S., Hyman R., Ferson T., Mazauskas C. Expression of Thy-1 glycoprotein on lectin-resistant lymphoma cell lines. Eur J Immunol. 1978 Oct;8(10):716–723. doi: 10.1002/eji.1830081009. [DOI] [PubMed] [Google Scholar]
- Tyan M. L. Allogeneic radiation chimeras. Long-term studies. Transplantation. 1975 Apr;19(4):326–334. doi: 10.1097/00007890-197504000-00008. [DOI] [PubMed] [Google Scholar]
- Wiktor-Jedrzejczak W., Sharkie S., Ahmed A., Sell K. W., Santos G. W. Theta-sensitive cell and erythropoiesis: identification of a defect in W/Wv anemic mice. Science. 1977 Apr 15;196(4287):313–315. doi: 10.1126/science.322288. [DOI] [PubMed] [Google Scholar]
- el-Arini M. O., Osoba D. Differentiation of thymus-derived cells from precursors in mouse bone marrow. J Exp Med. 1973 Mar 1;137(3):821–837. doi: 10.1084/jem.137.3.821. [DOI] [PMC free article] [PubMed] [Google Scholar]