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. 1979 Nov;38(3):577–583.

Effect of stimulation and blockade of mononuclear phagocyte system on the delayed footpad reaction to SRBC in mice.

Y Yoshikai, S Miake, T Matsumoto, K Nomoto, K Takeya
PMCID: PMC1457816  PMID: 521054

Abstract

The delayed footpad reaction to sheep erythrocytes (SRBC) was studied in mice whose mononuclear phagocyte system (MPS) was blocked or stimulated. Colloidal carbon or carrageenan was used for the blockade of MPS and Corynebacterium parvum or diethylstilbestrol used for the stimulation. The optimal dose of SRBC for the induction of the delayed footpad reaction was lower in MPS-blocked mice than in non-treated mice, whereas a high dose of SRBC was required for the induction of the strongest delayed footpad reaction in MPS-stimulated mice. These results suggest that non-specific phagocytic function of MPS modulates subsequent immune responses after administration of antigens.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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