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. 1979 Nov;38(3):447–458.

Mast cell membrane antigens and Fc receptors in anaphylaxis. I. Products of the major histocompatibility complex involved in alloantibody-induced mast cell activation.

M Daëron, G A Voisin
PMCID: PMC1457821  PMID: 521051

Abstract

Mast cell membrane antigens, coded by the K, I and D regions of the major histocompatibility complex of the mouse, were investigated for their presence at the cell surface and their participation in alloantibody-induced anaphylactic degranulation (DAAD). Anti-H-2 K, as well as anti-H-2 D antibodies were found to elicit DAAD. Recognition, on the mast cell membrane, of any product of the K or the D regions, either as the whole molecule, or as public or private antigens only, or even as a single private specificity, enabled alloimmune sera to trigger mast cell degranulation. By contrast, anti-Ia antibodies failed to elicit DAAD. By the autoradiographic technique, peritoneal mast cells were found to constitute a single homogeneous population, bearing H-2 D-coded antigens, although in smaller amounts than other peritoneal cells, but no Ia antigens or, if any, in much smaller amounts than other peritoneal cell type. These findings bring new evidence that mast cell alloantigens do participate in anaphylactic alloantibody-induced mast cell degranulation, by allowing bridging of (one?) Fc receptor with H-2 molecules.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brunner K. T., Mauel J., Schindler R. In vitro studies of cell-bound immunity; cloning assay of the cytotoxic action of sensitized lymphoid cells on allogeneic target cells. Immunology. 1966 Nov;11(5):499–506. [PMC free article] [PubMed] [Google Scholar]
  2. Cerottini J. C., Brunner K. T. Localization of mouse isoantigens on the cell surface as revealed by immunofluorescence. Immunology. 1967 Oct;13(4):395–403. [PMC free article] [PubMed] [Google Scholar]
  3. Chaouat G. Suppressor T cells in tolerance to human gamma-globulin: mediation by a specific soluble factor. Cell Immunol. 1978 Mar 1;36(1):1–14. doi: 10.1016/0008-8749(78)90245-9. [DOI] [PubMed] [Google Scholar]
  4. Daëron M., Duc H. T., Kanellopoulos J., Le Bouteiller P., Kinsky R., Voisin G. A. Allogenic mast cell degranulation induced by histocompatibility antibodies: an in vitro model of transplantation anaphylaxis. Cell Immunol. 1975 Dec;20(2):133–155. doi: 10.1016/0008-8749(75)90092-1. [DOI] [PubMed] [Google Scholar]
  5. Daëron M., Voisin G. A. H-2 antigens, on mast cell membrane, as target antigens for anaphylactic degranulation. Cell Immunol. 1978 May;37(2):467–472. doi: 10.1016/0008-8749(78)90214-9. [DOI] [PubMed] [Google Scholar]
  6. De Souza C. M., Maia L. C., Vaz N. M. Susceptibility to cutaneous anaphylaxis in inbred strains of mice. J Immunol. 1974 Apr;112(4):1369–1372. [PubMed] [Google Scholar]
  7. Frelinger J. A., Neiderhuber J. E., David C. S., Shreffler D. C. Evidence for the expression of Ia (H-2-associated) antigens on thymus-derived lymphocytes. J Exp Med. 1974 Nov 1;140(5):1273–1284. doi: 10.1084/jem.140.5.1273. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. HUMPHREY J. H., AUSTEN K. F., RAPP H. J. In vitro studies of reversed anaphylaxis with rat cells. Immunology. 1963 May;6:226–245. [PMC free article] [PubMed] [Google Scholar]
  9. HUNTER W. M., GREENWOOD F. C. Preparation of iodine-131 labelled human growth hormone of high specific activity. Nature. 1962 May 5;194:495–496. doi: 10.1038/194495a0. [DOI] [PubMed] [Google Scholar]
  10. Isersky C., Taurog J. D., Poy G., Metzger H. Triggering of cultured neoplastic mast cells by antibodies to the receptor for IgE. J Immunol. 1978 Aug;121(2):549–558. [PubMed] [Google Scholar]
  11. Ishizaka K., Ishizaka T. Immune mechanisms of reversed type reaginic hypersensitivity. J Immunol. 1969 Sep;103(3):588–595. [PubMed] [Google Scholar]
  12. Ishizaka K., Tomioka H., Ishizaka T. Mechanisms of passive sensitization. I. Presence of IgE and IgG molecules on human leukocytes. J Immunol. 1970 Dec;105(6):1459–1467. [PubMed] [Google Scholar]
  13. Ishizaka T., Chang T. H., Taggart M., Ishizaka K. Histamine release from rat mast cells by antibodies against rat basophilic leukemia cell membrane. J Immunol. 1977 Nov;119(5):1589–1596. [PubMed] [Google Scholar]
  14. Ishizaka T., Ishizaka K. Triggering of histamine release from rat mast cells by divalent antibodies against IgE-receptors. J Immunol. 1978 Mar;120(3):800–805. [PubMed] [Google Scholar]
  15. Krammer P. H., Hudson L., Sprent J. Fc-receptors, Ia-antigens, and immunoglobulin on normal and activated mouse T lymphocytes. J Exp Med. 1975 Dec 1;142(6):1403–1415. doi: 10.1084/jem.142.6.1403. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Le Bouteiller P., Daëron M., Duc H. T., Righenzi S., Voisin G. A. An ultrastructural study of two different responses of mouse mast cells to transplantation antibodies directed against the same transplantation antigens. Eur J Immunol. 1976 May;6(5):326–332. doi: 10.1002/eji.1830060505. [DOI] [PubMed] [Google Scholar]
  17. Lonai P., McDevitt H. O. I-region genes are expressed on T and B lymphocytes. Studies of the mixed lymphocyte reaction (MLR). J Exp Med. 1974 Nov 1;140(5):1317–1323. doi: 10.1084/jem.140.5.1317. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Mendoza G., Metzger H. Distribution and valency of receptor for IgE on rodent mast cells and related tumour cells. Nature. 1976 Dec 9;264(5586):548–550. doi: 10.1038/264548a0. [DOI] [PubMed] [Google Scholar]
  19. Murphy D. B., Shreffler D. C. Cross reactivity between H-2K and H-2D products. II. Identification of the cross reacting specificities. Transplantation. 1975 Dec;20(6):443–456. doi: 10.1097/00007890-197512000-00002. [DOI] [PubMed] [Google Scholar]
  20. Murphy D. B., Shrefler D. C. Cross-reactivity between H-2K and H-2D products. I. Evidence for extensive and reciprocal serological cross-reactivity. J Exp Med. 1975 Feb 1;141(2):374–391. doi: 10.1084/jem.141.2.374. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Nagai H., Kelly K., Sehon A. H. Antigen-, anti-F(ab')2- and anti-IgE-induced histamine release from rat mast cells. Int Arch Allergy Appl Immunol. 1978;56(3):264–272. doi: 10.1159/000232030. [DOI] [PubMed] [Google Scholar]
  22. Newman S. A., Rossi G., Metzger H. Molecular weight and valence of the cell-surface receptor for immunoglobulin E. Proc Natl Acad Sci U S A. 1977 Mar;74(3):869–872. doi: 10.1073/pnas.74.3.869. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Niederhuber J. E. The role of I region gene products in macrophage - T lymphocyte interaction. Immunol Rev. 1978;40:28–52. doi: 10.1111/j.1600-065x.1978.tb00400.x. [DOI] [PubMed] [Google Scholar]
  24. Schlessinger J., Webb W. W., Elson E. L., Metzger H. Lateral motion and valence of Fc receptors on rat peritoneal mast cells. Nature. 1976 Dec 9;264(5586):550–552. doi: 10.1038/264550a0. [DOI] [PubMed] [Google Scholar]
  25. Schwartz R. H., Dickler H. B., Sachs D. H., Schwartz B. D. Studies of Ia antigens on murine peritoneal macrophages. Scand J Immunol. 1976;5(6-7):731–743. doi: 10.1111/j.1365-3083.1976.tb03023.x. [DOI] [PubMed] [Google Scholar]
  26. Segal D. M., Taurog J. D., Metzger H. Dimeric immunoglobulin E serves as a unit signal for mast cell degranulation. Proc Natl Acad Sci U S A. 1977 Jul;74(7):2993–2997. doi: 10.1073/pnas.74.7.2993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Silver J., Hood L. Structure and evolution of transplantation antigens: partial amino-acid sequences of H-2K and H-2D alloantigens. Proc Natl Acad Sci U S A. 1976 Feb;73(2):599–603. doi: 10.1073/pnas.73.2.599. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Unanue E. R., Dorf M. E., David C. S., Benacerraf B. The presence of I-region-associated antigens on B cells in molecules distinct from immunoglobulin and H-2K and H-2D. Proc Natl Acad Sci U S A. 1974 Dec;71(12):5014–5016. doi: 10.1073/pnas.71.12.5014. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Vitetta E. S., Capra J. D. The protein products of the murine 17th chromosome: genetics and structure. Adv Immunol. 1978;26:147–193. doi: 10.1016/s0065-2776(08)60230-8. [DOI] [PubMed] [Google Scholar]

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