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. 1980 Apr;39(4):589–598.

An immunosuppressive factor in the serum of baboons (Papio anubis) infected with Schistosoma mansoni.

B J Cottrell, R F Sturrock, M Vanhoegaerden
PMCID: PMC1458023  PMID: 6445872

Abstract

Serum taken from baboons infected with Schistosoma mansoni was able to suppress in vitro reactivity of normal baboon lymphocytes. The concanavalin A response was significantly suppressed by such serum, whereas the specific suppression of the phytohaemagglutinin response was minimal. Serum from S. mansoni infected donors also depressed the mixed lymphocyte reactions to xenogeneic targets, but did not affect the specific transformation of lymphocytes stimulated with a parasite Ag. Significant suppressive activity occurred in the baboon serum from 4 to 11 weeks after the initial infection. Serum from animals with a chronic infection of 6-42 months, did not suppress in vitro cell-mediated immunity. The suppressive factor was heat-stable, non-dialysable and, following ultracentrifugation of the suppressive serum, was found to be present in the high mol. wt fraction. From these studies, it is suggested that the immunosuppressive factors are immune complexes, which appear in the serum of the baboons following their infection with this blood parasite.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bullock W. E., Jr, Fasal P. Studies of immune mechanisms in leprosy. 3. The role of cellular and humoral factors in impairment of the in vitro immune response. J Immunol. 1971 Apr;106(4):888–899. [PubMed] [Google Scholar]
  2. Chess L., Schlossman S. F. Human lymphocyte subpopulations. Adv Immunol. 1977;25:213–241. doi: 10.1016/s0065-2776(08)60934-7. [DOI] [PubMed] [Google Scholar]
  3. Colley D. G., Hieny S. E., Bartholomew R. K., Cook J. A. Immune responses during human schistosomiasis mansoni. III. Regulatory effect of patient sera on human lymphocyte blastogenic responses to schistosome antigen preparations. Am J Trop Med Hyg. 1977 Sep;26(5 Pt 1):917–925. [PubMed] [Google Scholar]
  4. Colley D. G., Lewis F. A., Goodgame R. W. Immune responses during human schistosomiasis mansoni. IV. Induction of suppressor cell activity by schistosome antigen preparations and concanavalin A. J Immunol. 1978 Apr;120(4):1225–1232. [PubMed] [Google Scholar]
  5. Coulis P. A., Lewert R. M., Fitch F. W. Splenic suppressor cells and cell-mediated cytotoxicity in murine schistosomiasis. J Immunol. 1978 Mar;120(3):1074–1076. [PubMed] [Google Scholar]
  6. Creighton W. D., Lambert P. H., Miescher P. A. Detection of antibodies and soluble antigen-antibody complexes by precipitation with polyethylene glycol. J Immunol. 1973 Oct;111(4):1219–1227. [PubMed] [Google Scholar]
  7. Dessaint J. P., Camus D., Fischer E., Capron A. Inhibition of lymphocyte proliferation by factor(s) produced by Schistosoma mansoni. Eur J Immunol. 1977 Sep;7(9):624–629. doi: 10.1002/eji.1830070909. [DOI] [PubMed] [Google Scholar]
  8. Dickler H. B. Lymphocyte receptors for immunoglobulin. Adv Immunol. 1976;24:167–214. doi: 10.1016/s0065-2776(08)60330-2. [DOI] [PubMed] [Google Scholar]
  9. Houba V., Koech D. K., Sturrock R. F., Butterworth A. E., Kusel J. R., Mahmoud A. A. Soluble antigens and antibodies in sera from baboons infected with Schistosoma mansoni. J Immunol. 1976 Aug;117(2):705–707. [PubMed] [Google Scholar]
  10. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  11. Mangi R. J., Dwyer J. M., Kantor F. S. The effect of plasma upon lymphocyte response in vitro. Demonstration of a humoral inhibitor in patients with sarcoidosis. Clin Exp Immunol. 1974 Dec;18(4):519–528. [PMC free article] [PubMed] [Google Scholar]
  12. Moretta L., Mingari M. C., Romanzi C. A. Loss of Fc receptors for IgG from human T lymphocytes exposed to IgG immune complexes. Nature. 1978 Apr 13;272(5654):618–620. doi: 10.1038/272618a0. [DOI] [PubMed] [Google Scholar]
  13. Pelley R. P., Ruffier J. J., Warren K. S. Suppressive effect of a chronic helminth infection, schistosomiasis mansoni, on the in vitro responses of spleen and lymph node cells to the T cell mitogens phytohemagglutinin and concanavalin A. Infect Immun. 1976 Apr;13(4):1176–1183. doi: 10.1128/iai.13.4.1176-1183.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Playfair J. H. Effective and ineffective immune responses to parasites: evidence from experimental models. Curr Top Microbiol Immunol. 1978;80:37–64. doi: 10.1007/978-3-642-66956-9_2. [DOI] [PubMed] [Google Scholar]
  15. Ramalho-Pinto F. J., De Souza J. B., Playfair J. H. Stimulation and suppression of response of mouse T cells to the schistosomules of Schistosoma mansoni during infection. Nature. 1976 Feb 19;259(5544):603–604. doi: 10.1038/259603a0. [DOI] [PubMed] [Google Scholar]
  16. Ryan J. L., Arbeit R. D., Dickler H. B., Henkart P. A. Inhibition of lymphocyte mitogenesis by immobilized antigen-antibody complexes. J Exp Med. 1975 Oct 1;142(4):814–826. doi: 10.1084/jem.142.4.814. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Stout R. D., Herzenberg L. A. The Fc receptor on thymus-derived lymphocytes: II. Mitogen responsiveness of T lymphocytes bearing the Fc receptor. J Exp Med. 1975 Nov 1;142(5):1041–1051. doi: 10.1084/jem.142.5.1041. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Stout R. D., Waksal S. D., Herzenberg L. A. The Fc receptor on thymus-derived lymphocytes. III. Mixed lymphocyte reactivity and cell-mediated lympholytic activity of Fc- and Fc+ T lymphocytes. J Exp Med. 1976 Jul 1;144(1):54–68. doi: 10.1084/jem.144.1.54. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Sturrock R. F., Butterworth A. E., Houba V. Schistosoma mansoni in the baboon (Papio anubis): parasitological responses of Kenyan baboons to different exposures of a local parasite strain. Parasitology. 1976 Dec;73(3):239–252. doi: 10.1017/s003118200004693x. [DOI] [PubMed] [Google Scholar]
  20. Wicher V., Wicher K. In vitro cell response of Treponema pallidum-infected rabbits. II. Inhibition of lymphocyte response to phytohaemagglutinin by serum of T. pallidum-infected rabbits. Clin Exp Immunol. 1977 Sep;29(3):487–495. [PMC free article] [PubMed] [Google Scholar]

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