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. 1980 Jul;40(3):335–342.

Specific and non-specific suppressor cell activity in NZB mice.

A Cooke, P Hutchings, R Nayak
PMCID: PMC1458064  PMID: 6159307

Abstract

Non-specific and specific suppressor cell activity has been examined in both young and old NZB mice and compared to normal CBA mice. Both young and old NZB mice are shown to be able to generate antigen non-specific and specific suppressor cells in response to Con A and rat RBC respectively. In addition, antigen-specific suppressor cells which suppress the experimental induction of red cell autoantibodies do not influence the spontaneous development or course of autoimmune haemolytic anaemia. Subsequent experiments showed that this is probably due to differences in specificity of induced and spontaneous autoantibodies.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barthold D. R., Kysela S., Steinberg A. D. Decline in suppressor T cell function with age in female NZB mice. J Immunol. 1974 Jan;112(1):9–16. [PubMed] [Google Scholar]
  2. Cantor H., McVay-Boudreau L., Hugenberger J., Naidorf K., Shen F. W., Gershon R. K. Immunoregulatory circuits among T-cell sets. II. Physiologic role of feedback inhibition in vivo: absence in NZB mice. J Exp Med. 1978 Apr 1;147(4):1116–1125. doi: 10.1084/jem.147.4.1116. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Cerottini J. C., Lambert P. H., Dixon F. J. Comparison of the immune responsiveness of NZB and NZB X NZW F1 hybrid mice with that of other strains of mice. J Exp Med. 1969 Nov 1;130(5):1093–1105. doi: 10.1084/jem.130.5.1093. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Chused T. M., Steinberg A. D., Parker L. M. Enhanced antibody response of mice to polyinosinic-polycytidylic acid by antithymocyte serum and its age-dependent loss in NZB-W mice. J Immunol. 1973 Jul;111(1):52–57. [PubMed] [Google Scholar]
  5. Cooke A., Hutchings P. R., Playfair J. H. Suppressor T cells in experimental autoimmune haemolytic anaemia. Nature. 1978 May 11;273(5658):154–155. doi: 10.1038/273154a0. [DOI] [PubMed] [Google Scholar]
  6. Cooke A., Playfair J. H. Hyper-responsiveness in NZB mice to the experimental induction of anti-red cell autoantibody. Clin Exp Immunol. 1977 Mar;27(3):538–544. [PMC free article] [PubMed] [Google Scholar]
  7. Cox K. O., Keast D. Autoimmune haemolytic anaemia induced in mice immunized with rat erythrocytes. Clin Exp Immunol. 1974 Jun;17(2):319–327. [PMC free article] [PubMed] [Google Scholar]
  8. Cunningham A. J., Szenberg A. Further improvements in the plaque technique for detecting single antibody-forming cells. Immunology. 1968 Apr;14(4):599–600. [PMC free article] [PubMed] [Google Scholar]
  9. Falkoff R. M., Scavulli J. F., Dutton R. W. Independent analysis of T helper and T killer cell function in young and old NZB mice. J Immunol. 1978 Sep;121(3):897–902. [PubMed] [Google Scholar]
  10. Feldmann M., Easten A. The relationship between antigenic structure and the requirement for thymus-derived cells in the immune response. J Exp Med. 1971 Jul 1;134(1):103–119. doi: 10.1084/jem.134.1.103. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Gerber N. L., Hardin J. A., Chused T. M., Steinberg A. D. Loss with age in NZB-W mice of thymic suppressor cells in the graft-vs-host reaction. J Immunol. 1974 Nov;113(5):1618–1625. [PubMed] [Google Scholar]
  12. Gershwin M. E., Ikeda R. M., Kruse W. L., Wilson F., Shifrine M., Spangler W. Age-dependent loss in New Zealand mice of morphological and functional characteristics of thymic epithelial cells. J Immunol. 1978 Mar;120(3):971–979. [PubMed] [Google Scholar]
  13. Izui S., McConahey P. J., Dixon F. J. Increased spontaneous polyclonal activation of B lymphocytes in mice with spontaneous autoimmune disease. J Immunol. 1978 Dec;121(6):2213–2219. [PubMed] [Google Scholar]
  14. Julius M. H., Simpson E., Herzenberg L. A. A rapid method for the isolation of functional thymus-derived murine lymphocytes. Eur J Immunol. 1973 Oct;3(10):645–649. doi: 10.1002/eji.1830031011. [DOI] [PubMed] [Google Scholar]
  15. Klassen L. W., Krakauer R. S., Steinberg A. D. Selective loss of suppressor cell function in New Zealand mice induced by NTA. J Immunol. 1977 Sep;119(3):830–830. [PubMed] [Google Scholar]
  16. Mage M. G., McHugh L. L., Rothstein T. L. Mouse lymphocytes with and without surface immunoglobulin: preparative scale separation in polystyrene tissue culture dishes coated with specifically purified anti-immunoglobulin. J Immunol Methods. 1977;15(1):47–56. doi: 10.1016/0022-1759(77)90016-3. [DOI] [PubMed] [Google Scholar]
  17. Moutsopoulos H. M., Boehm-Truitt M., Kassan S. S., Chused T. M. Demonstration of activation of B lymphocytes in New Zealand black mice at birth by an immunoradiometric assay for murine IgM. J Immunol. 1977 Nov;119(5):1639–1644. [PubMed] [Google Scholar]
  18. Playfair J. H., Marshall-Clarke S. Induction of red cell autoantibodies in normal mice. Nat New Biol. 1973 Jun 13;243(128):213–214. doi: 10.1038/newbio243213a0. [DOI] [PubMed] [Google Scholar]
  19. RUBIN H. Antibody elution from red blood cells. J Clin Pathol. 1963 Jan;16:70–73. doi: 10.1136/jcp.16.1.70. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Shirai T., Hayakawa K., Okumura K., Tada T. Differential cytotoxic effect of natural thymocytotoxic autoantibody of NZB mice on functional subsets of T cells. J Immunol. 1978 Jun;120(6):1924–1929. [PubMed] [Google Scholar]
  21. Staples P. J., Talal N. Relative inability to induce tolerance in adult NZB and NZB-NZW F1 mice. J Exp Med. 1969 Jan 1;129(1):123–139. doi: 10.1084/jem.129.1.123. [DOI] [PMC free article] [PubMed] [Google Scholar]

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