Skip to main content
NCBI home page
Immunology logoLink to Immunology
. 1980 Aug;40(4):621–627.

The influence of cigarette tobacco smoke products on the immune response. The cellular basis of immunosuppression by a water-soluble condensate of tobacco smoke.

C V Jacob, G T Stelzer, J H Wallace
PMCID: PMC1458096  PMID: 7000690

Abstract

The immunosuppression exhibited by a water-soluble condensate of tobacco smoke (WSC) has been studied in vivo and in vitro. When multiple sublethal doses of WSC were injected into C57Bl/6 mice, their ability to respond to immunization with sheep erythrocytes by the formation of plaque-forming cells was severely inhibited. In addition, spleen cells from WSC-treated mice were unable to mount a primary response to SRBC in vitro. Studies on the cellular basis of the immunosuppression induced by WSC showed a decrease in T lymphocytes in the spleens of WSC-treated mice. Additional experiments were conducted in which isolated populations of T cells, B cells and macrophages from WSC-treated or normal mice were combined and then tested for responsiveness to SRBC in vitro. Results of these experiments also indicated that T cells were particularly susceptible to WSC exposure. T cells from WSC-treated mice were unable to co-operate with normal B cells and macrophages in the response to SRBC. A less marked suppression of B-cell function was noted in condensate-treated mice. While B cells from such animals were able to co-operate with normal T cells and macrophages to give a detectable primary response to SRBC, the response was depressed. In contrast, macrophages from WSC-treated animals enhanced the response of normal T and B cells to SRBC.

Full text

PDF
621

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Allison A. C., Law L. W. Effects of antilymphocyte serum on virus oncogenesis. Proc Soc Exp Biol Med. 1968 Jan;127(1):207–212. doi: 10.3181/00379727-127-32657. [DOI] [PubMed] [Google Scholar]
  2. Allison A. C., Taylor R. B. Observations on thymectomy and carcinogenesis. Cancer Res. 1967 Apr;27(4):703–707. [PubMed] [Google Scholar]
  3. Baldwin R. W. Immunological aspects of chemical carcinogenesis. Adv Cancer Res. 1973;18:1–75. doi: 10.1016/s0065-230x(08)60750-2. [DOI] [PubMed] [Google Scholar]
  4. Bullock W. W., Möller E. "Spontaneous" B cell activation due to loss of normal mouse serum suppressor. Eur J Immunol. 1972 Dec;2(6):514–517. doi: 10.1002/eji.1830020609. [DOI] [PubMed] [Google Scholar]
  5. Golub E. S. Brain-associated theta antigen: reactivity of rabbit anti-mouse brain with mouse lymphoid cells. Cell Immunol. 1971 Aug;2(4):353–361. doi: 10.1016/0008-8749(71)90070-0. [DOI] [PubMed] [Google Scholar]
  6. HANKS J. H., WALLACE J. H. Determination of cell viability. Proc Soc Exp Biol Med. 1958 May;98(1):188–192. doi: 10.3181/00379727-98-23985. [DOI] [PubMed] [Google Scholar]
  7. Holt P. G., Keast D. Environmentally induced changes in immunological function: acute and chronic effects of inhalation of tobacco smoke and other atmospheric contaminants in man and experimental animals. Bacteriol Rev. 1977 Mar;41(1):205–216. doi: 10.1128/br.41.1.205-216.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Reif A. E., Allen J. M. Mouse thymic iso-antigens. Nature. 1966 Jan 29;209(5022):521–523. doi: 10.1038/209521b0. [DOI] [PubMed] [Google Scholar]
  9. Roszman T. L., Rogers A. S. The immunosuppressive potential of products derived from cigarette smoke. Am Rev Respir Dis. 1973 Nov;108(5):1158–1163. doi: 10.1164/arrd.1973.108.5.1158. [DOI] [PubMed] [Google Scholar]
  10. Thomas W. R., Holt P. G., Keast D. Cellular immunity in mice chronically exposed to fresh cigarette smoke. Arch Environ Health. 1973 Dec;27(6):372–375. doi: 10.1080/00039896.1973.10666406. [DOI] [PubMed] [Google Scholar]
  11. Thomas W., Holt P. G., Keast D. Effect of cigarette smoking on primary and secondary humoral responses of mice. Nature. 1973 May 25;243(5404):240–241. doi: 10.1038/243240a0. [DOI] [PubMed] [Google Scholar]
  12. Van Duuren B. L., Sivak A., Segal A., Orris L., Langseth L. The tumor-promoting agents of tobacco leaf and tobacco smoke condensate. J Natl Cancer Inst. 1966 Oct;37(4):519–526. [PubMed] [Google Scholar]
  13. Wellhausen S. R., Mansfield J. M. Lymphocyte function in experimental African trypanosomiasis. II. Splenic suppressor cell activity. J Immunol. 1979 Mar;122(3):818–824. [PubMed] [Google Scholar]

Articles from Immunology are provided here courtesy of British Society for Immunology

RESOURCES