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. 1980 Aug;40(4):687–694.

Age-related changes in cell localization and proliferation in lymph nodes and spleen after antigenic stimulation.

J D Ansell, C M McDougall, H S Micklem, C J Inchley
PMCID: PMC1458099  PMID: 7429546

Abstract

Antigen-dependent localization of 51Cr-labelled lymphocytes, and the subsequent uptake of IUdR into lymphoid organs has been studied as a function of age. Measures of cell localization indicated that while old age can alter the patterns of entry of lymphocytes into lymph nodes and spleen, these changes are variable and probably not sufficient alone to explain decreased primary antibody responses in old animals. Proliferation of cells, however, was consistently affected in both organs and this phenomenon is discussed in terms of abnormal T-cell function.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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