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. 1980 Sep;41(1):83–90.

Comparability of delayed hypersensitivity in various rodents. II. Jones-Mote type hypersensitivity in guinea-pigs immunized with sheep erythrocytes and its modification by cyclophosphamide or BCG pre-treatment.

K Nomoto, S Yoshida, K Himeno
PMCID: PMC1458219  PMID: 7429556

Abstract

Guinea-pigs were immunized via footpads with sheep red blood cells (SRBC) in saline. Histological examination of erythematous skin reaction was performed and effects of cyclophosphamide (CY) or BCG pre-treatment on the skin reaction were examined. Delayed-in-onset erythematous skin reaction accompanied by substantial basophil infiltration was elicited in guinea-pigs immunized with SRBC in saline. The erythema was augmented in size by CY which was injected 2 days before immunization. The reaction may be comparable to Jones-Mote type. In BCG pre-treated guinea-pigs, basophil infiltration at the skin reaction sites was reduced in number, but significant inhibition of macrophage migration was not detected in the presence of SRBC antigen. The reaction may be intermediate between Jones-Mote and the tuberculin type. Comparability of delayed skin reactions in guinea-pigs and delayed footpad reactions in mice or hamsters against SRBC is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Askenase P. W., Haynes J. D., Hayden B. J. Antibody-mediated basophil accumulations in cutaneous hypersensitivity reactions of guinea pigs. J Immunol. 1976 Jul;117(1):216–224. [PubMed] [Google Scholar]
  2. Colvin R. B., Pinn V. W., Simpson B. A., Dvorak H. F. Cutaneous basophil hypersensitivity. IV. The "late reaction": sequel to Jones-Mote type hypersensitivity. Comparison with rabbit Arthus reaction. Effect of passive antibody on induction and expression of Jones-Mote hypersensitivity. J Immunol. 1973 May;110(5):1279–1289. [PubMed] [Google Scholar]
  3. Dvorak H. F., Dvorak A. M., Simpson B. A., Richerson H. B., Leskowitz S., Karnovsky M. J. Cutaneous basophil hypersensitivity. II. A light and electron microscopic description. J Exp Med. 1970 Sep 1;132(3):558–582. doi: 10.1084/jem.132.3.558. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Dvorak H. F., Hammond M. E., Colvin R. B., Manseau E. J., Goodwin J. Systemic expression of cutaneous basophil hypersensitivity. J Immunol. 1977 May;118(5):1549–1557. [PubMed] [Google Scholar]
  5. GEORGE M., VAUGHAN J. H. In vitro cell migration as a model for delayed hypersensitivity. Proc Soc Exp Biol Med. 1962 Nov;111:514–521. doi: 10.3181/00379727-111-27841. [DOI] [PubMed] [Google Scholar]
  6. Himeno K., Nomoto K., Takeya K. Effects of cyclophosphamide on the expression and induction of delayed hypersensitivity. Microbiol Immunol. 1978;22(11):719–730. doi: 10.1111/j.1348-0421.1978.tb00425.x. [DOI] [PubMed] [Google Scholar]
  7. Jokipii A. M., Jokipii L. Suppression of cell-mediated immunity by cyclophosphamide: its independence of concomitant B cell response. Cell Immunol. 1973 Dec;9(3):477–481. doi: 10.1016/0008-8749(73)90063-4. [DOI] [PubMed] [Google Scholar]
  8. Katz S. I., Heather C. J., Parker D., Turk J. L. Basophilic leukocytes in delayed hypersensitivity reactions. J Immunol. 1974 Oct;113(4):1073–1078. [PubMed] [Google Scholar]
  9. Katz S. I., Parker D., Turk J. L. Mechanisms involved in the expression of Jones-Mote hypersensitivity. II. Lymph node morphology and in vitro correlates. Cell Immunol. 1975 Apr;16(2):404–412. doi: 10.1016/0008-8749(75)90129-x. [DOI] [PubMed] [Google Scholar]
  10. Lagrange P. H., Mackaness G. B. A stable form of delayed-type hypersensitivity. J Exp Med. 1975 Jan 1;141(1):82–96. doi: 10.1084/jem.141.1.82. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Lagrange P. H., Mackaness G. B., Miller T. E. Influence of dose and route of antigen injection on the immunological induction of T cells. J Exp Med. 1974 Mar 1;139(3):528–542. doi: 10.1084/jem.139.3.528. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Lagrange P. H., Mackaness G. B., Miller T. E. Potentiation of T-cell-mediated immunity by selective suppression of antibody formation with cyclophosphamide. J Exp Med. 1974 Jun 1;139(6):1529–1539. doi: 10.1084/jem.139.6.1529. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Mackaness G. B., Lagrange P. H., Ishibashi T. The modifying effect of BCG on the immunological induction of T cells. J Exp Med. 1974 Jun 1;139(6):1540–1552. doi: 10.1084/jem.139.6.1540. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Miller T. E., Mackaness G. B., Lagrange P. H. Immunopotentiation with BCG. II. Modulation of the response to sheep red blood cells. J Natl Cancer Inst. 1973 Nov;51(5):1669–1676. doi: 10.1093/jnci/51.5.1669. [DOI] [PubMed] [Google Scholar]
  15. Mitsuoka A., Teramatsu T., Baba M., Morikawa S., Yasuhira K. Delayed hypersensitivity in mice induced by intravenous sensitization with sheep erythrocytes: evidence for tuberculin type delayed hypersensitivity of the reaction. Immunology. 1978 Mar;34(3):363–370. [PMC free article] [PubMed] [Google Scholar]
  16. Ohmichi Y., Nomoto K., Yamada H., Takeya K. Relationships among differentiated T-cell subpopulations. I. Dissociated development of tuberculin type hypersensitivity, Jones-Mote type hypersensitivity and activation of helper function. Immunology. 1976 Jul;31(1):101–110. [PMC free article] [PubMed] [Google Scholar]
  17. Stadecker M. J., Leskowitz S. The cutaneous basophil response to mitogens. J Immunol. 1974 Aug;113(2):496–500. [PubMed] [Google Scholar]
  18. Turk J. L., Parker D., Poulter L. W. Functional aspects of the selective depletion of lymphoid tissue by cyclophosphamide. Immunology. 1972 Oct;23(4):493–501. [PMC free article] [PubMed] [Google Scholar]
  19. Waterston R. H. Soluble antigen from sheep erythrocytes: preparation and antigenic properties. Immunology. 1970 Mar;18(3):431–435. [PMC free article] [PubMed] [Google Scholar]
  20. Yoshida S. I., Nomoto K., Yamada H., Himeno K., Takeya K. Comparability of delayed hypersensitivity in various rodents. I. Regulatory mechanism of delayed footpad reactions in the hamster. Cell Immunol. 1977 Dec;34(2):231–246. doi: 10.1016/0008-8749(77)90246-5. [DOI] [PubMed] [Google Scholar]
  21. Yoshida S., Nomoto K., Himeno K. Dissociation of erythema and basophil accumulation in Jones-Mote type hypersensitivity in the guinea-pig. Br J Exp Pathol. 1979 Dec;60(6):596–603. [PMC free article] [PubMed] [Google Scholar]

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